Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.
These two authors contributed equally to this article as lead authors and supervised the work.
Eur Respir J. 2021 Aug 5;58(2). doi: 10.1183/13993003.03005-2020. Print 2021 Aug.
Around 8-10% of individuals over 50 years of age present interstitial lung abnormalities (ILAs), but their risk factors are uncertain.
From 817 individuals recruited in our lung ageing programme at the Mexican National Institute of Respiratory Diseases, 80 (9.7%) showed ILAs and were compared with 564 individuals of the same cohort with normal high-resolution computed tomography to evaluate demographic and functional differences, and with 80 individuals randomly selected from the same cohort for biomarkers. We evaluated variant rs35705950, telomere length, and serum levels of matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, interleukin (IL)-6, surfactant protein (SP)-D, α-Klotho and resistin.
Individuals with ILAs were usually males (p<0.005), older than controls (p<0.0001), smokers (p=0.01), with a greater frequency of rs35705950 (OR 3.5, 95% CI 1.3-9.4; p=0.01), and reduced diffusing capacity of the lung for carbon monoxide and oxygen saturation. Resistin, IL-6, SP-D, MMP-1, MMP-7 and MMP-13 were significantly increased in individuals with ILAs. Resistin (12±5 9±4 ng·mL; p=0.0005) and MMP-13 (357±143 298±116 pg·mL; p=0.004) were the most increased biomarkers. On follow-up (24±18 months), 18 individuals showed progression which was associated with gastro-oesophageal reflux disease (OR 4.1, 95% CI 1.2-12.9; p=0.02) and in females with diabetes mellitus (OR 5.3, 95% CI 1.0-27.4; p=0.01).
Around 10% of respiratory asymptomatic individuals enrolled in our lung ageing programme show ILAs. Increased serum concentrations of pro-inflammatory molecules and MMPs are associated with ILAs.
80 岁以上人群中约有 8-10%存在肺间质异常（ILA），但其危险因素尚不确定。
从我们在墨西哥国家呼吸疾病研究所进行的肺部老化计划中招募的 817 名个体中，有 80 名（9.7%）存在 ILA，并与同队列的 564 名高分辨率计算机断层扫描正常的个体进行比较，以评估人口统计学和功能差异，并与同队列中随机选择的 80 名个体进行生物标志物比较。我们评估了变体 rs35705950、端粒长度以及血清基质金属蛋白酶（MMP）-1、MMP-2、MMP-3、MMP-7、MMP-8、MMP-9、MMP-12、MMP-13、白细胞介素（IL）-6、表面活性剂蛋白（SP）-D、α-Klotho 和抵抗素的水平。
有 ILA 的个体通常为男性（p<0.005），比对照组更年长（p<0.0001），是吸烟者（p=0.01），rs35705950 的频率更高（OR 3.5，95%CI 1.3-9.4；p=0.01），并且一氧化碳弥散量和氧饱和度降低。有 ILA 的个体中抵抗素、IL-6、SP-D、MMP-1、MMP-7 和 MMP-13 显著增加。抵抗素（12±5 9±4ng·mL；p=0.0005）和 MMP-13（357±143 298±116pg·mL；p=0.004）是增加最明显的生物标志物。在随访（24±18 个月）中，18 名个体出现进展，这与胃食管反流病（OR 4.1，95%CI 1.2-12.9；p=0.02）和女性糖尿病（OR 5.3，95%CI 1.0-27.4；p=0.01）有关。
在我们的肺部老化计划中招募的 80 岁以上无症状呼吸人群中，约有 10%存在 ILA。血清中促炎分子和 MMPs 浓度升高与 ILA 有关。
