通过钯催化的α-烷基烯醇醚的氧化还原接力Heck烯基化反应对烷基烯丙基醚进行对映选择性合成。
Enantioselective Synthesis of Alkyl Allyl Ethers via Palladium-Catalyzed Redox-Relay Heck Alkenylation of -Alkyl Enol Ethers.
作者信息
Prater Matthew B, Sigman Matthew S
机构信息
Department of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, UT, 84112.
出版信息
Isr J Chem. 2020 Mar;60(3-4):452-460. doi: 10.1002/ijch.201900077. Epub 2019 Sep 11.
Abstract
Herein we report a transformation that generates an array of enantiomerically enriched, alkyl allyl ethers. Cyclic, acyclic, and heteroatom-bearing alkenyl triflates undergo an enantioselective, palladium-catalyzed C-C bond formation with diverse acyclic -alkyl enol ethers in good yields and excellent enantioselectivities.
摘要
在此，我们报道了一种转化反应，该反应能生成一系列对映体富集的烷基烯丙基醚。环状、非环状和含杂原子的烯基三氟甲磺酸酯与多种非环状的α-烷基烯醇醚发生对映选择性的钯催化碳-碳键形成反应，产率良好，对映选择性优异。
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