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支持观点:支气管镜检查对于血液系统恶性肿瘤患者的肺部感染至关重要。

Pro: Bronchoscopy is essential for pulmonary infections in patients with haematological malignancies.

作者信息

Milliken Eliza J T, Davis Joshua S

机构信息

Dept of Infectious Diseases, John Hunter Hospital, Newcastle, Australia.

School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.

出版信息

Breathe (Sheff). 2020 Dec;16(4):200228. doi: 10.1183/20734735.0228-2020.

Abstract

Up to 60% of patients with haematological malignancy will develop pulmonary infiltrates at some point in their disease course. Bronchoscopy should be used early in patients without respiratory failure as diagnostic yield is highest in the first 1-2 days of illness. Perceptions that patients with haematological malignancy are at higher risk of complications from bronchoscopy has led to a reluctance to perform the procedure. However, cohort studies have not demonstrated any increase in complications for this specific patient group. Common concerns include mucosal injury, respiratory impairment and haemorrhage. However, prospective cohort studies demonstrate that this patient group do not experience a higher than baseline level of complications. Specific pathogen diagnosis reduces morbidity and mortality in lung infection. Additionally, complex infections with multidrug-resistant organisms, the increasing prevalence of which is largely driven by empirical antibiotic use, make specific diagnosis more crucial than ever if we are to maintain our ability to manage myelosuppressive therapies and stem cell transplant.

摘要

高达60%的血液系统恶性肿瘤患者在病程的某个阶段会出现肺部浸润。对于没有呼吸衰竭的患者,应尽早进行支气管镜检查,因为在发病后的头1 - 2天诊断阳性率最高。人们认为血液系统恶性肿瘤患者接受支气管镜检查出现并发症的风险更高,这导致医生不愿进行该检查。然而,队列研究并未表明这一特定患者群体的并发症有任何增加。常见的担忧包括黏膜损伤、呼吸功能损害和出血。然而,前瞻性队列研究表明,该患者群体的并发症发生率并未高于基线水平。明确病原体诊断可降低肺部感染的发病率和死亡率。此外,耐多药微生物引起的复杂感染(其患病率的增加很大程度上是由经验性使用抗生素所致),如果我们要维持管理骨髓抑制疗法和干细胞移植的能力,那么明确诊断比以往任何时候都更为关键。

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