Van Ly David, Wang Duo, Conway Robert Max, Giblin Michael, Liang Sharron, Lukeis Robyn, Lim Li-Anne, Hesson Luke, Cherepanoff Svetlana
Anatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
School of Medicine, The University of Notre Dame Australia, Sydney, New South Wales, Australia.
Ocul Oncol Pathol. 2020 Dec;6(6):416-421. doi: 10.1159/000510393. Epub 2020 Oct 9.
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.
葡萄膜黑色素瘤（UM）是成人中最常见的原发性眼内恶性肿瘤。关于UM中脂质生成的已发表数据有限。在此，我们描述了一例伴有脂质生成及HMG-CoA还原酶表达的睫状体脉络膜黑色素瘤的临床、组织学、免疫组织化学和分子学发现。该病例突出了一种具有高风险分子转移特征的不寻常UM肿瘤表型，并讨论了肿瘤脂肪生成及甲羟戊酸途径的激活作为治疗脂质化睫状体脉络膜UM的潜在治疗靶点。
