McCusker Megan R, Bazinet Richard P, Metherel Adam H, Klein Roberta Yael, Kundra Arjun, Haibe-Kains Benjamin, Li Madeline
Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, Canada.
Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
Curr Dev Nutr. 2020 Oct 13;4(11):nzaa156. doi: 10.1093/cdn/nzaa156. eCollection 2020 Nov.
Nonesterified fatty acids (NEFAs) are known to have inflammatory effects. The inflammatory hypothesis of depression suggests that omega-3 (ω-3) and omega-6 (ω-6) fatty acids might be negatively and positively correlated with depression, respectively.
An exploratory study was conducted to determine the association between dietary free fatty acids and depressive symptoms in cancer patients and caregivers.
Associations between depression and the NEFA pool were investigated in 56 cancer patients and 23 caregivers using a combination of nonparametric tests and regularized regression. Plasma NEFAs were measured using thin layer and gas chromatography with flame ionization detection. Depression was characterized both as a continuous severity score using the GRID-Hamilton Depression Rating Scale (GRID Ham-D), and as a categorical diagnosis of major depression by structured clinical interview.
Initial hypotheses regarding the relation between depression and omega-3 or omega-6 fatty acids were not well supported. However, elaidic acid, a -unsaturated fatty acid found in hydrogenated vegetable oils, was found to be negatively correlated with continuous depression scores in cancer patients. No significant associations were found in caregivers.
An unexpected negative association between elaidic acid and depression was identified, supporting recent literature on the role of G protein-coupled receptors in depression. Further research is needed to confirm this result and to evaluate the potential role of G protein agonists as therapeutic agents for depression in cancer patients.
已知非酯化脂肪酸（NEFAs）具有炎症作用。抑郁症的炎症假说表明，ω-3（ω-3）脂肪酸和ω-6（ω-6）脂肪酸可能分别与抑郁症呈负相关和正相关。
进行一项探索性研究，以确定癌症患者及其照料者的膳食游离脂肪酸与抑郁症状之间的关联。
采用非参数检验和正则回归相结合的方法，对56例癌症患者和23名照料者进行了抑郁症与NEFA库之间的关联研究。使用薄层色谱和带有火焰离子化检测的气相色谱法测量血浆NEFAs。抑郁既通过使用汉密尔顿抑郁量表（GRID Ham-D）作为连续严重程度评分来表征，也通过结构化临床访谈作为重度抑郁症的分类诊断来表征。
关于抑郁症与ω-3或ω-6脂肪酸之间关系的初始假设未得到充分支持。然而，发现氢化植物油中存在的反式不饱和脂肪酸反油酸与癌症患者的连续抑郁评分呈负相关。在照料者中未发现显著关联。
确定了反油酸与抑郁症之间存在意外的负相关，这支持了最近关于G蛋白偶联受体在抑郁症中作用的文献。需要进一步研究以证实这一结果，并评估G蛋白激动剂作为癌症患者抑郁症治疗药物的潜在作用。
