Wösten Monique, Baldus Stephan, Pfister Roman
Department of Cardiology, Heart Center, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Eur Heart J Case Rep. 2020 Dec 13;4(6):1-4. doi: 10.1093/ehjcr/ytaa451. eCollection 2020 Dec.
Tricuspid regurgitation (TR) is the most frequent valvular complication after cardiac transplantation. As in native hearts, the role of surgical therapy particularly in secondary TR is unclear due to high procedural risk and unsatisfying results. Currently, percutaneous techniques are under development for TR repair with less procedural risk and promising preliminary results.
We present a 67-year-old man who underwent heart transplantation (biatrial anastomosis) because of ischaemic heart disease 15 years ago and aortic valve replacement in 2010. Because of progressive severe dyspnoea (New York Heart Association Class III) in 2018 and signs of right heart failure with ascites he underwent transthoracic echocardiography which showed normal graft function, but massive TR of functional aetiology. The heart team decision was an interventional approach using the Cardioband System (Edwards Lifesciences) to treat TR based on the high risk associated with a third cardiac surgery and impaired right ventricular function. The procedure was performed in general anaesthesia with transoesophageal echocardiography and fluoroscopic guidance. Tricuspid regurgitation improved from massive to mild with a mean pressure gradient of 2.9 mmHg.
This is the first case report of Cardioband implantation in tricuspid position in a heart transplant patient with the good technical and clinical result, suggesting that this technique might offer a treatment option to highly selected post-transplant patients with secondary severe TR and high surgical risk.
三尖瓣反流(TR)是心脏移植后最常见的瓣膜并发症。与天然心脏一样,由于手术风险高且效果不尽人意,手术治疗尤其是继发性TR的作用尚不清楚。目前,经皮技术正在开发用于TR修复,其手术风险较低且初步结果令人鼓舞。
我们报告一名67岁男性,15年前因缺血性心脏病接受心脏移植(双心房吻合术),2010年接受主动脉瓣置换术。由于2018年进行性严重呼吸困难(纽约心脏协会III级)以及出现右心衰竭伴腹水的体征,他接受了经胸超声心动图检查,结果显示移植心脏功能正常,但存在功能性病因导致的大量TR。心脏团队决定采用介入方法,使用Cardioband系统(爱德华生命科学公司)治疗TR,这是基于第三次心脏手术的高风险以及右心室功能受损。该手术在全身麻醉下进行,采用经食管超声心动图和荧光透视引导。三尖瓣反流从大量改善为轻度,平均压力阶差为2.9 mmHg。
这是心脏移植患者三尖瓣位置植入Cardioband的首例病例报告,技术和临床效果良好,表明该技术可能为高度选择的继发性严重TR且手术风险高的移植后患者提供一种治疗选择。