• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hypothesis: Unrecognized actions of ENaC blockade in improving refractory-resistant hypertension and residual cardiovascular risk.

作者信息

Elijovich Fernando, Kirabo Annet, Laffer Cheryl L

机构信息

Division of Clinical Pharmacology. Department of Medicine. Vanderbilt University School of Medicine, 2220 Pierce Ave, 536 RRB, Nashville, TN, 37232, USA.

出版信息

Int J Cardiol Hypertens. 2020 Sep 12;7:100048. doi: 10.1016/j.ijchy.2020.100048. eCollection 2020 Dec.

DOI:10.1016/j.ijchy.2020.100048
PMID:33447773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7803029/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/414d/7803029/f2244fbe2227/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/414d/7803029/f2244fbe2227/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/414d/7803029/f2244fbe2227/gr1.jpg

相似文献

1
Hypothesis: Unrecognized actions of ENaC blockade in improving refractory-resistant hypertension and residual cardiovascular risk.假设：上皮钠通道（ENaC）阻滞剂在改善难治性高血压和残余心血管风险方面存在未被认识的作用。
Int J Cardiol Hypertens. 2020 Sep 12;7:100048. doi: 10.1016/j.ijchy.2020.100048. eCollection 2020 Dec.
2
Hyperactive ENaC identifies hypertensive individuals amenable to amiloride therapy.高活性上皮钠通道可识别适合氨氯吡咪治疗的高血压个体。
Am J Physiol Cell Physiol. 2001 Nov;281(5):C1413-21. doi: 10.1152/ajpcell.2001.281.5.C1413.
3
Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride.心血管疾病中的上皮钠通道抑制。氨氯吡咪的潜在作用。
Am J Hypertens. 2007 Jan;20(1):109-17. doi: 10.1016/j.amjhyper.2006.05.022.
4
The epithelial sodium channel in hypertension: genetic heterogeneity and implications for treatment with amiloride.高血压中的上皮钠通道：遗传异质性及氨氯吡咪治疗的意义。
Am J Pharmacogenomics. 2004;4(3):161-8.
5
Resistant Hypertension On Treatment (ResHypOT): sequential nephron blockade compared to dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol in the treatment of resistant arterial hypertension - study protocol for a randomized controlled trial.治疗中难治性高血压（ResHypOT）：与肾素-血管紧张素-醛固酮系统双重阻断加比索洛尔相比，序贯肾单位阻断治疗难治性动脉高血压——一项随机对照试验的研究方案
Trials. 2018 Feb 12;19(1):101. doi: 10.1186/s13063-017-2343-3.
6
Epithelial sodium channel blockade and new β-ENaC polymorphisms among normotensive and hypertensive adult Nigerians.上皮钠离子通道阻断和新的β-ENaC 多态性在正常血压和高血压的尼日利亚成年人中。
Clin Exp Hypertens. 2019;41(2):144-151. doi: 10.1080/10641963.2018.1451538. Epub 2018 Mar 26.
7
Amiloride lowers blood pressure and attenuates urine plasminogen activation in patients with treatment-resistant hypertension.氨氯吡咪可降低顽固性高血压患者的血压并减弱尿纤溶酶原激活作用。
J Am Soc Hypertens. 2014 Dec;8(12):872-81. doi: 10.1016/j.jash.2014.09.019.
8
Compensatory up-regulation of angiotensin II subtype 1 receptors in alpha ENaC knockout heterozygous mice.αENaC基因敲除杂合小鼠中血管紧张素II 1型受体的代偿性上调。
Kidney Int. 2001 Jun;59(6):2216-21. doi: 10.1046/j.1523-1755.2001.00739.x.
9
PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.PCSK9 缺乏症不会改变高血压小鼠模型中的血压和钠平衡。
Atherosclerosis. 2015 Mar;239(1):252-9. doi: 10.1016/j.atherosclerosis.2015.01.012. Epub 2015 Jan 19.
10
Central role for ENaC in development of hypertension.上皮钠通道（ENaC）在高血压发展中的核心作用。
J Am Soc Nephrol. 2005 Nov;16(11):3154-9. doi: 10.1681/ASN.2005050460. Epub 2005 Sep 28.

引用本文的文献

1
Novel formylpeptide receptor 1/2 agonist limits hypertension-induced cardiovascular damage.新型甲酰肽受体 1/2 激动剂可限制高血压引起的心血管损伤。
Cardiovasc Res. 2024 Sep 21;120(11):1336-1350. doi: 10.1093/cvr/cvae103.
2
High residual cardiovascular risk after lipid-lowering: prime time for Predictive, Preventive, Personalized, Participatory, and Psycho-cognitive medicine.降脂治疗后仍存在较高心血管残余风险：预测性、预防性、个性化、参与性及心理认知医学的黄金时期。
Front Cardiovasc Med. 2023 Oct 16;10:1264319. doi: 10.3389/fcvm.2023.1264319. eCollection 2023.
3
Renal denervation in the antihypertensive arsenal - knowns and known unknowns.

本文引用的文献

1
Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation.钠通过 NADPH 氧化酶和异亮氨酸衍生的小肽激活人单核细胞。
Cardiovasc Res. 2021 Apr 23;117(5):1358-1371. doi: 10.1093/cvr/cvaa207.
2
Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association.《心脏病与卒中统计-2020 更新：来自美国心脏协会的报告》。
Circulation. 2020 Mar 3;141(9):e139-e596. doi: 10.1161/CIR.0000000000000757. Epub 2020 Jan 29.
3
Effects of Interleukin-1β Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk: A Secondary Analysis of CANTOS.
在降压武器库中，肾脏去神经术——已知与未知。
J Hypertens. 2022 Oct 1;40(10):1859-1875. doi: 10.1097/HJH.0000000000003171.
白细胞介素-1β 抑制对血压、新发高血压和残留炎症风险的影响：CANTOS 的二次分析。
Hypertension. 2020 Feb;75(2):477-482. doi: 10.1161/HYPERTENSIONAHA.119.13642. Epub 2019 Dec 30.
4
Dendritic Cell A20: Targeting Hypertension in Autoimmunity.树突状细胞A20：针对自身免疫性疾病中的高血压
Circ Res. 2019 Dec 6;125(12):1067-1069. doi: 10.1161/CIRCRESAHA.119.316198. Epub 2019 Dec 5.
5
High Salt Activates CD11c Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension.高盐通过 SGK1（血清糖皮质激素激酶 1）激活 CD11c 抗原呈递细胞，促进肾脏炎症和盐敏感性高血压。
Hypertension. 2019 Sep;74(3):555-563. doi: 10.1161/HYPERTENSIONAHA.119.12761. Epub 2019 Jul 8.
6
High dietary salt-induced dendritic cell activation underlies microbial dysbiosis-associated hypertension.高盐饮食诱导树突状细胞激活是微生物失调相关高血压的基础。
JCI Insight. 2019 Jun 4;5(13):126241. doi: 10.1172/jci.insight.126241.
7
Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.耐药性高血压：检测、评估与管理：美国心脏协会科学声明。
Hypertension. 2018 Nov;72(5):e53-e90. doi: 10.1161/HYP.0000000000000084.
8
Two Pools of Epoxyeicosatrienoic Acids in Humans: Alterations in Salt-Sensitive Normotensive Subjects.人体中的两种环氧二十碳三烯酸池：盐敏感型正常血压受试者的变化。
Hypertension. 2018 Feb;71(2):346-355. doi: 10.1161/HYPERTENSIONAHA.117.10392. Epub 2017 Dec 26.
9
Salt-responsive gut commensal modulates T17 axis and disease.盐反应性肠道共生菌调节T17轴与疾病。
Nature. 2017 Nov 30;551(7682):585-589. doi: 10.1038/nature24628. Epub 2017 Nov 15.
10
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.树突状细胞阿米洛利敏感通道介导钠诱导的炎症和高血压。
Cell Rep. 2017 Oct 24;21(4):1009-1020. doi: 10.1016/j.celrep.2017.10.002.