Department of Obstetrics and Perinatology, University Hospital, Cracow, Poland.
Department of Obstetrics & Perinatology, Jagiellonian University Medical College, Cracow, Poland (employed until 2019).
Ginekol Pol. 2020;91(12):726-732. doi: 10.5603/GP.2020.0119.
Induction of labour is a part of an active prenatal care nowadays and the ideal method of that procedure still remains to be identified. The purpose of this study was to evaluate effectiveness of misoprostol vaginal insert as compared to dinoprostone gel for delivery induction in pregnant women without any comorbidities.
It was a retrospective cohort study of 240 pregnant women. The primary study outcome was successful delivery. Other analysed parameters included time to delivery of a baby, time to the beginning of the first stage of labour, time to vaginal delivery, and duration of all delivery stages. We compared both methods regarding maternal complications during and after delivery. We also reviewed neonatal outcomes such as birth weight, birth length and 1-minute Apgar scores.
The patients' basic characteristics were similar regarding their age, gravidity, parity, height, weight and Bishop score. Time to any delivery and to the onset of a labour in the misoprostol group versus in the dinoprostone group was 14.5 vs 35.6 h (p < 0.001) and 9.9 h vs 25.3 h (p < 0.001) respectively. The chance of the beginning of labour and the baby's delivery over time has been observed to be approximately two times higher for misoprostol as compared to dinoprostone.
Our study showed that using misoprostol vaginal insert in comparison to dinoprostone seems to shorten the time to beginning of the first stage of labour as well as the time to the delivery itself. Some lower Apgar scores observed in the misoprostol group requires further investigation.
引产是当今主动产前护理的一部分，理想的引产方法仍有待确定。本研究旨在评估米索前列醇阴道栓剂与地诺前列酮凝胶在无任何合并症的孕妇中用于引产的效果。
这是一项回顾性队列研究，共纳入 240 名孕妇。主要研究结果是分娩成功。其他分析参数包括分娩时间、第一产程开始时间、阴道分娩时间和所有分娩阶段的持续时间。我们比较了这两种方法在分娩期间和分娩后产妇并发症的情况。我们还回顾了新生儿结局，如出生体重、出生长度和 1 分钟 Apgar 评分。
患者的基本特征在年龄、孕次、产次、身高、体重和 Bishop 评分方面相似。米索前列醇组与地诺前列酮组的任何分娩时间和第一产程开始时间分别为 14.5 小时与 35.6 小时（p<0.001）和 9.9 小时与 25.3 小时（p<0.001）。随着时间的推移，米索前列醇组开始分娩和婴儿分娩的机会大约是地诺前列酮组的两倍。
我们的研究表明，与地诺前列酮相比，使用米索前列醇阴道栓剂似乎可以缩短第一产程开始的时间以及分娩本身的时间。米索前列醇组观察到的一些较低的 1 分钟 Apgar 评分需要进一步研究。
