Department of Obstetrics and Gynecology, Dicle University Medical Faculty, Diyarbakır, Turkey.
Department of Biochemistry, Dicle University Medical Faculty, Diyarbakir, Turkey.
Ginekol Pol. 2020;91(12):733-739. doi: 10.5603/GP.a2020.0124.
To investigate the levels of anti-angiogenic factors, namely sFlt-1 and Netrin-4, in patients with preeclampsia (PE).
Cord-blood (UC) sFlt-1 and Netrin-4 concentrations were measured in 30 patients with severe PE, 30 patients with PE and 30 control infants and their mothers (MS).
Maternal sFlt-1 levels were significantly higher in the severe PE and PE groups than in the control group. There were no statistical differences among the three groups in maternal and fetal Netrin-4 levels. But Netrin-4 levels were found to be the lowest in the control group and higher in the PE and severe PE groups. The correlation analysis revealed a positive correlation between maternal sFlt-1 levels and maternal Netrin-4 levels (p = 0.012, and r = 0.263), maternal sFlt-1 levels and fetal sFlt-1 levels (p = 0.012, and r = 0.263).
There was a positive correlation found between maternal sFlt-1 levels and maternal Netrin-4 levels. We are of the opinion that elevation in levels of Netrin-4 might be secondary to placental hypoxia occurring in PE. The present study led to the consideration of anti-angiogenic biomarkers (sFlt-1 and Netrin-4) on automated platforms for clinical use as an aid in establishing the diagnosis and prognosis of PE.
研究抗血管生成因子 sFlt-1 和 Netrin-4 在子痫前期（PE）患者中的水平。
测量 30 例重度 PE 患者、30 例 PE 患者和 30 例对照婴儿及其母亲（MS）的脐血（UC） sFlt-1 和 Netrin-4 浓度。
重度 PE 和 PE 组的母体 sFlt-1 水平明显高于对照组。三组母体和胎儿 Netrin-4 水平无统计学差异。但 Netrin-4 水平在对照组最低，PE 和重度 PE 组较高。相关性分析显示母体 sFlt-1 水平与母体 Netrin-4 水平呈正相关（p = 0.012，r = 0.263），母体 sFlt-1 水平与胎儿 sFlt-1 水平呈正相关（p = 0.012，r = 0.263）。
母体 sFlt-1 水平与母体 Netrin-4 水平呈正相关。我们认为 Netrin-4 水平的升高可能是 PE 中胎盘缺氧的继发反应。本研究考虑将抗血管生成生物标志物（sFlt-1 和 Netrin-4）用于自动化平台进行临床应用，以辅助 PE 的诊断和预后。
