Department of Medical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Int J Clin Pract. 2021 May;75(5):e14023. doi: 10.1111/ijcp.14023. Epub 2021 Jan 24.
Children with inflammatory bowel disease (IBD) generally show an alteration in their fat and soft tissue mass contents. These alterations may influence disease severity and increase the risk of post-operative complications.
This is a retrospective cross-sectional study of patients with IBD, diagnosed and followed up between 2013 and 2018, in Jeddah, Saudi Arabia, who had dual-energy x-ray absorptiometry (DXA) scans for bone density evaluation. Obesity was defined based on fat mass index (FMI) and myopenia based on appendicular skeletal muscle mass (SMMa).
This study incorporated 95 child and adolescent patients (52% female) with IBD: 59 with Crohn's disease (CD) and 36 with ulcerative colitis (UC), mean age 11.8 ± 3.3 years and mean duration of illness 1.8 ± 1.9 years. The most common disease phenotype and behaviour for CD patients were ileocolonic (57.6%) and non-stricturing and non-penetrating (76.3%). Of UC patients, 75% had extensive disease (pancolitis). Body composition profile in the total IBD cohort was classified as normal in 49.5%, obese in 26.3%, myopenic in 23.2% and myopenic-obese in 1.1%. The use of biological therapy was identified as a negative predictor for both obesity (OR = 7.0, 95% CI: 1.3-37.9, P = .02) and myopenia (OR = 0.11, 95% CI:0.02-0.47, P = .003), and female gender was shown to predict myopenia (OR = 3.5, 95% CI: 1.0-11.8, P = .04).
Saudi Arabian children with IBD showed comparable body composition profiles to adult patients with IBD. Biological therapy was associated with a decreased incidence of both obesity and myopenia, and female gender was found to predict myopenia.
患有炎症性肠病（IBD）的儿童通常表现出脂肪和软组织质量含量的改变。这些改变可能会影响疾病的严重程度并增加术后并发症的风险。
这是一项在沙特阿拉伯吉达进行的回顾性横断面研究，纳入了 2013 年至 2018 年间诊断和随访的 IBD 患者，这些患者进行了双能 X 射线吸收法（DXA）扫描以评估骨密度。肥胖是根据脂肪量指数（FMI）定义的，肌肉减少症是根据四肢骨骼肌质量（SMMa）定义的。
本研究纳入了 95 名儿童和青少年 IBD 患者（52%为女性）：59 名克罗恩病（CD）患者和 36 名溃疡性结肠炎（UC）患者，平均年龄 11.8±3.3 岁，疾病平均病程为 1.8±1.9 年。CD 患者最常见的疾病表型和行为是回结肠（57.6%）和非狭窄性非穿透性（76.3%）。UC 患者中，75%为广泛性疾病（全结肠炎）。在 IBD 患者的总体身体成分谱中，49.5%为正常，26.3%为肥胖，23.2%为肌肉减少症，1.1%为肌肉减少症和肥胖。生物治疗的使用被确定为肥胖（OR=7.0，95%CI：1.3-37.9，P=.02）和肌肉减少症（OR=0.11，95%CI：0.02-0.47，P=.003）的负预测因子，女性被发现是肌肉减少症的预测因子（OR=3.5，95%CI：1.0-11.8，P=.04）。
沙特阿拉伯的 IBD 儿童与成人 IBD 患者的身体成分谱相似。生物治疗与肥胖和肌肉减少症的发生率降低有关，而女性被发现是肌肉减少症的预测因子。
