Yang Zeran, Zhang Xin, Ma Jie, Jin Li, He Xujun
Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
Institute of Clinical Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 Dec 25;49(6):725-731. doi: 10.3785/j.issn.1008-9292.2020.12.07.
To study the expression of tumor associated vascular insulin receptor (TVIR) in colorectal cancer with or without metabolic syndrome (MS) and its relationship with the pathological features of colorectal cancer.
The expression of TVIR in 220 colorectal cancer specimens was detected by tissue microarray and immunohistochemistry. The relationships between the expression of TVIR and the pathological features (pathological subtypes, histological grade, invasion depth, lymph node metastasis and TNM stage) of colorectal cancer with/without MS were analyzed.
The insulin receptor expression was observed in colorectal cancer tissue or border area between cancer and normal tissue, but not in normal intestinal tissue. The high-expression rates of TVIR in MS group was remarkably lower than that of non-MS group (21.6%vs. 41.0%, < 0.05). TVIR high expression was significantly associated with tumor deep invasion, lymph node metastasis and high TNM stage (<0.05 or <0.01). Univariate logistic regression analysis showed high-expression of TVIR to be significantly associated with risk of deep invasion (=2.21, 95% : 1.10-4.44, <0.05), lymph node metastasis (=2.21, 95% : 1.26-3.86, <0.01) and high TNM stage (=2.08, 95% : 1.19-3.63, <0.05). Such associations can be observed in patients without MS, but not in patients with MS.
s: High-expression of TVIR is associated with aggressive pathological features such as invasion, lymph node metastasis and high TNM stage of colorectal cancer, especially for those patients without MS. TVIR could be a useful biological marker for prognosis of colorectal cancer.
研究肿瘤相关血管胰岛素受体（TVIR）在伴或不伴代谢综合征（MS）的结直肠癌中的表达情况及其与结直肠癌病理特征的关系。
采用组织芯片和免疫组化法检测220例结直肠癌标本中TVIR的表达。分析TVIR表达与伴或不伴MS的结直肠癌病理特征（病理亚型、组织学分级、浸润深度、淋巴结转移及TNM分期）之间的关系。
胰岛素受体在结直肠癌组织或癌与正常组织交界处有表达，而在正常肠组织中无表达。MS组TVIR高表达率显著低于非MS组（21.6%对41.0%，<0.05）。TVIR高表达与肿瘤深度浸润、淋巴结转移及高TNM分期显著相关（<0.05或<0.01）。单因素logistic回归分析显示，TVIR高表达与深度浸润风险显著相关（=2.21，95%：1.10 - 4.44，<0.05）、淋巴结转移（=2.21，95%：1.26 - 3.86，<0.01）及高TNM分期（=2.08，95%：1.19 - 3.63，<0.05）。这种相关性在无MS的患者中可见，但在有MS的患者中未见。
TVIR高表达与结直肠癌的侵袭、淋巴结转移及高TNM分期等侵袭性病理特征相关，尤其是在无MS的患者中。TVIR可能是结直肠癌预后的一个有用生物标志物。
