[Expression of tumor-associated vascular insulin receptor in colorectal cancer and its relationship with tumor pathological features].

OBJECTIVE

To study the expression of tumor associated vascular insulin receptor (TVIR) in colorectal cancer with or without metabolic syndrome (MS) and its relationship with the pathological features of colorectal cancer.

METHODS

The expression of TVIR in 220 colorectal cancer specimens was detected by tissue microarray and immunohistochemistry. The relationships between the expression of TVIR and the pathological features (pathological subtypes, histological grade, invasion depth, lymph node metastasis and TNM stage) of colorectal cancer with/without MS were analyzed.

RESULTS

The insulin receptor expression was observed in colorectal cancer tissue or border area between cancer and normal tissue, but not in normal intestinal tissue. The high-expression rates of TVIR in MS group was remarkably lower than that of non-MS group (21.6%vs. 41.0%, < 0.05). TVIR high expression was significantly associated with tumor deep invasion, lymph node metastasis and high TNM stage (<0.05 or <0.01). Univariate logistic regression analysis showed high-expression of TVIR to be significantly associated with risk of deep invasion (=2.21, 95% : 1.10-4.44, <0.05), lymph node metastasis (=2.21, 95% : 1.26-3.86, <0.01) and high TNM stage (=2.08, 95% : 1.19-3.63, <0.05). Such associations can be observed in patients without MS, but not in patients with MS.

CONCLUSIONS

s: High-expression of TVIR is associated with aggressive pathological features such as invasion, lymph node metastasis and high TNM stage of colorectal cancer, especially for those patients without MS. TVIR could be a useful biological marker for prognosis of colorectal cancer.