MRN 复合物是 DNA 损伤修复的必需效应因子。
MRN complex is an essential effector of DNA damage repair.
机构信息
The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.
Zhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Haining 314400, China.
出版信息
J Zhejiang Univ Sci B. 2021 Jan 15;22(1):31-37. doi: 10.1631/jzus.B2000289.
Genome stability can be threatened by both endogenous and exogenous agents. Organisms have evolved numerous mechanisms to repair DNA damage, including homologous recombination (HR) and non-homologous end joining (NHEJ). Among the factors associated with DNA repair, the MRE11-RAD50-NBS1 (MRN) complex (MRE11-RAD50-XRS2 in ) plays important roles not only in DNA damage recognition and signaling but also in subsequent HR or NHEJ repair. Upon detecting DNA damage, the MRN complex activates signaling molecules, such as the protein kinase ataxia-telangiectasia mutated (ATM), to trigger a broad DNA damage response, including cell cycle arrest. The nuclease activity of the MRN complex is responsible for DNA end resection, which guides DNA repair to HR in the presence of sister chromatids. The MRN complex is also involved in NHEJ, and has a species-specific role in hairpin repair. This review focuses on the structure of the MRN complex and its function in DNA damage repair.
基因组稳定性可能受到内源性和外源性因素的威胁。生物已经进化出许多机制来修复 DNA 损伤，包括同源重组 (HR) 和非同源末端连接 (NHEJ)。在与 DNA 修复相关的因素中，MRE11-RAD50-NBS1 (MRN) 复合物（在中称为 MRE11-RAD50-XRS2）不仅在 DNA 损伤识别和信号转导中发挥重要作用，而且在随后的 HR 或 NHEJ 修复中也发挥重要作用。在检测到 DNA 损伤后，MRN 复合物激活信号分子，如共济失调毛细血管扩张突变蛋白激酶 (ATM)，触发广泛的 DNA 损伤反应，包括细胞周期停滞。MRN 复合物的核酸酶活性负责 DNA 末端切除，在存在姐妹染色单体的情况下指导 DNA 修复至 HR。MRN 复合物还参与 NHEJ，并在发夹修复中具有种特异性作用。这篇综述重点介绍了 MRN 复合物的结构及其在 DNA 损伤修复中的功能。
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