Cui Xuewei, Wang Ye, Fu Jianhua
Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.
Cell Biosci. 2025 Aug 2;15(1):114. doi: 10.1186/s13578-025-01442-6.
The integrity and stability of DNA, an essential genetic material, need to be maintained for normal cellular function, growth, and development. The DNA damage response (DDR) constitutes a complex, sophisticated, and extensive signaling network that preserves genomic stability under stress. It can be divided into the DNA damage surveillance system and DNA damage repair system, which work in concert to ensure genomic integrity. When DNA damage surpasses the repair capacity of the DDR, unrepaired DNA damage accumulates, inducing cellular senescence and altering the fate of alveolar epithelial cells; this process is intricately linked to the onset, progression, and management of developmental and chronic lung diseases. In this review, recent research on the pathogenic mechanisms of DDR in respiratory diseases across the lifespan, including bronchopulmonary dysplasia, bronchial asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis, as well as progress in the development of associated targeted therapeutic strategies, is synthesized.
DNA作为一种重要的遗传物质，其完整性和稳定性对于细胞的正常功能、生长和发育至关重要。DNA损伤反应（DDR）构成了一个复杂、精密且广泛的信号网络，在应激状态下维持基因组稳定性。它可分为DNA损伤监测系统和DNA损伤修复系统，二者协同工作以确保基因组完整性。当DNA损伤超过DDR的修复能力时，未修复的DNA损伤会积累，诱导细胞衰老并改变肺泡上皮细胞的命运；这一过程与发育性和慢性肺部疾病的发生、发展及治疗密切相关。在本综述中，综合了近年来关于DDR在整个生命周期的呼吸系统疾病（包括支气管肺发育不良、支气管哮喘、慢性阻塞性肺疾病和特发性肺纤维化）发病机制的研究，以及相关靶向治疗策略的进展。
