Service de Médecine et Biologie de la Reproduction, Hôpital Mère et Enfant, CHU de Nantes, Nantes, France.
Faculté de Médecine, Nantes, France.
Hum Fertil (Camb). 2022 Jul;25(3):600-606. doi: 10.1080/14647273.2021.1873431. Epub 2021 Jan 15.
Anti-Mullerian Hormone (AMH) is considered to be one of the most relevant markers of ovarian reserve. However, its association with oocyte quality, pregnancy occurrence and evolution remain to be further investigated. The objective of this study was to compare miscarriage rate after fresh blastocyst(s) transfer in young women (<37 years old) with or without diminished ovarian reserve (DOR), as reflected by low serum AMH levels. This monocentric retrospective study was conducted in 669 women undergoing 1,891 blastocyst transfers. Patients were divided into 2 groups: (1) 190 transfers performed in 106 women with a 'low' serum AMH (< 10th percentile) (i.e. AMH < 0.85 ng/mL); and (2) 961 transfers performed in 563 patients with a 'normal' serum AMH (25th-75th percentile) (i.e. AMH 1.4-4 ng/mL). Miscarriage rate was comparable in both groups (9.5 and 6.8% respectively; = 0.2) as well as implantation rate, pregnancy rate, live birth rate per transfer ( = 0.4, = 0.07 and = 0.6, respectively). After multivariate analysis, no significant association was found between serum AMH level and miscarriage rate ( = 0.22). In women <37 years, low serum AMH level is not associated with an increase in miscarriage rate after fresh blastocyst transfer.
抗苗勒氏管激素（AMH）被认为是卵巢储备功能的最相关标志物之一。然而，其与卵母细胞质量、妊娠发生和进展的关系仍需进一步研究。本研究旨在比较血清 AMH 水平较低（<10 百分位数）的年轻女性（<37 岁）和血清 AMH 水平正常（25-75 百分位数）的年轻女性新鲜囊胚（s）移植后的流产率。这项单中心回顾性研究纳入了 669 名接受 1891 次囊胚移植的患者。患者分为 2 组：（1）106 名血清 AMH 较低（<10 百分位数）的患者进行了 190 次移植（即 AMH<0.85ng/ml）；（2）563 名血清 AMH 正常（25-75 百分位数）的患者进行了 961 次移植（即 AMH 1.4-4ng/ml）。两组的流产率（分别为 9.5%和 6.8%， = 0.2）、种植率、妊娠率和每周期活产率相当（ = 0.4、 = 0.07 和 = 0.6）。多变量分析后，血清 AMH 水平与流产率之间无显著相关性（ = 0.22）。在<37 岁的女性中，血清 AMH 水平较低与新鲜囊胚移植后的流产率增加无关。
