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当肿块样脱髓鞘真的是肿瘤时:影像学误诊病例报告。

When tumefactive demyelination is truly a tumor: case report of a radiographic misdiagnosis.

机构信息

Department of Pharmacy, University of Miami Health System, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.

Department of Pharmacy, Duke University Hospital, The Preston Robert Tisch Brain Tumor Center, Durham, NC 27710, USA.

出版信息

CNS Oncol. 2021 Mar 1;10(1):CNS69. doi: 10.2217/cns-2020-0028. Epub 2021 Jan 15.

DOI:10.2217/cns-2020-0028
PMID:33448234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7962173/
Abstract

Oligodendrogliomas are slow-growing tumors that account for 15-20% of gliomas. This case report describes the case of an adult male patient diagnosed initially with tumefactive demyelination and multiple sclerosis, which was subsequently found to be a well-differentiated low-grade oligodendroglioma. This case emphasizes the importance of timely diagnosis in oligodendrogliomas and other brain tumors for the prompt initiation of appropriate therapy, to minimize the likelihood of disease progression, ensure symptom management and escalation of unnecessary treatments for multiple sclerosis.

摘要

少突胶质细胞瘤生长缓慢,占胶质瘤的 15-20%。本病例报告描述了一例最初诊断为肿块样脱髓鞘病变和多发性硬化症的成年男性患者,随后发现为分化良好的低级别少突胶质细胞瘤。本病例强调了及时诊断少突胶质细胞瘤和其他脑肿瘤的重要性,以便及时启动适当的治疗,最大限度地降低疾病进展的可能性,确保症状管理,并避免对多发性硬化症进行不必要的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c34/7962173/2bd0a8a3b8e6/cns-10-69-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c34/7962173/2bd0a8a3b8e6/cns-10-69-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c34/7962173/2bd0a8a3b8e6/cns-10-69-g1.jpg

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本文引用的文献

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Mult Scler. 2020 Dec;26(14):1816-1821. doi: 10.1177/1352458520970841. Epub 2020 Nov 11.
2
A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma.一例多发性硬化症与间变性星形细胞瘤并发的疑难病例。
Surg Neurol Int. 2019 Aug 23;10:166. doi: 10.25259/SNI_176_2019. eCollection 2019.
3
Pseudotumoral demyelinating lesions: diagnostic approach and long-term outcome.
假瘤样脱髓鞘病变:诊断方法和长期预后。
Curr Opin Neurol. 2019 Jun;32(3):467-474. doi: 10.1097/WCO.0000000000000683.
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Magnetic Resonance Imaging in Multiple Sclerosis.磁共振成像在多发性硬化中的应用。
Cold Spring Harb Perspect Med. 2018 May 1;8(5):a028969. doi: 10.1101/cshperspect.a028969.
5
Tumefactive demyelinating lesions of 15 patients: Clinico-radiological features, management and review of the literature.15 例肿块样脱髓鞘病变患者:临床-放射学特征、处理及文献复习。
J Neurol Sci. 2017 Oct 15;381:32-38. doi: 10.1016/j.jns.2017.08.005. Epub 2017 Aug 12.
6
Update on disease-modifying therapies for multiple sclerosis.多发性硬化症疾病修正疗法的最新进展。
J Investig Med. 2017 Jun;65(5):883-891. doi: 10.1136/jim-2016-000339. Epub 2017 Jan 27.
7
Is size an essential criterion to define tumefactive plaque? MR features and clinical correlation in multiple sclerosis.大小是定义瘤样斑块的必要标准吗?多发性硬化症的磁共振成像特征及临床相关性
Neuroradiol J. 2016 Oct;29(5):384-9. doi: 10.1177/1971400916665385. Epub 2016 Aug 16.
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Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders.多发性硬化及相关疾病中的肿胀性脱髓鞘病变
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