肌球蛋白在产生 Th17 和 IL-22 的 ILC3 中高度富集，并抑制小鼠结肠炎中的促炎细胞因子。
Musculin is highly enriched in Th17 and IL-22-producing ILC3s and restrains pro-inflammatory cytokines in murine colitis.
机构信息
Institute of Surgery Research, Army Medical University, Chongqing, China.
The 5th Medical Center of PLA General Hospital, Beijing, China.
出版信息
Eur J Immunol. 2021 Apr;51(4):995-998. doi: 10.1002/eji.202048573. Epub 2021 Feb 2.
Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC mice survived DSS-induced colitis, MSC mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC mice by IL-22 antagonism suggests the existence of MSC:IL-22 regulatory axis.
转录抑制因子肌细胞生成素（MSC）在促炎 Th17 和产生 IL-22 的 ILC3 中富集。虽然 MSC 小鼠在 DSS 诱导的结肠炎中存活下来，但 MSC 小鼠表现出更高的促炎细胞因子，更严重的病理，体重减轻，更早死亡。IL-22 拮抗作用逆转 MSC 小鼠的结肠炎症状表明存在 MSC:IL-22 调节轴。
Zotero 插件