RTI International, Chicago, IL, USA.
Bryan School of Business and Economics, University of North Carolina, Greensboro, NC, USA.
Addiction. 2021 May;116(5):1034-1042. doi: 10.1111/add.15224. Epub 2020 Aug 27.
To estimate US population health utilities for subgroups defined by alcohol use disorder (AUD) status and consumption level.
Cross-sectional survey.
Community settings in the United States (i.e. excluding institutional settings).
A total of 36,042 adults (age 18+) in non-institutional settings in the United States.
We used 12-item Short Form Survey (SF-12) data from the National Epidemiologic Survey on Alcohol and Related Conditions-III to calculate mean Short Form-6 dimension (SF-6D) utility scores across World Health Organization alcohol consumption risk levels-very high risk, high risk, medium risk, low risk and an additional abstinent level-for three groups: (1) the general population (n = 36,042), (2) individuals with life-time AUD (n = 9925) and (3) individuals with current AUD (n = 5083), and assessed minimally important differences (MIDs) between consumption levels. Each group is a subset of the previous group.
The general population's mean SF-6D utility was higher than that of individuals with life-time or current AUD across all consumption risk levels (0.79 versus 0.76 for both AUD groups). For all groups, SF-6D utilities increased as consumption risk level decreased to non-abstinent levels, and reducing consumption from very high risk to any lower level was associated with a statistically significant and meaningful improvement in utility. For individuals with life-time or current AUD, becoming abstinent from high-, medium- and low-risk levels was associated with significantly and meaningfully worse utilities.
Higher alcohol consumption risk levels appear to be associated with lower health index scores for the general population and individuals with a history of alcohol use disorder, meaning that higher alcohol consumption is associated with worse health-related quality of life.
估计按酒精使用障碍(AUD)状态和消费水平定义的亚组的美国人口健康效用。
横断面调查。
美国社区环境(即不包括机构环境)。
美国非机构环境中共有 36042 名 18 岁以上成年人。
我们使用来自国家酒精与相关状况流行病学调查-III 的 12 项简短表格调查(SF-12)数据,根据世界卫生组织酒精消费风险水平(极高风险、高风险、中风险、低风险和额外的禁欲水平)计算出一般人群(n=36042)、(2)终身 AUD 个体(n=9925)和(3)当前 AUD 个体(n=5083)的平均简短表格-6 维度(SF-6D)效用评分,并评估了消费水平之间的最小重要差异(MIDs)。每个组都是前一组的子集。
在所有消费风险水平下,一般人群的平均 SF-6D 效用均高于终身或当前 AUD 个体(AUD 两个组的平均值分别为 0.79 和 0.76)。对于所有组,随着消费风险水平降低到非禁欲水平,SF-6D 效用增加,从极高风险减少到任何较低水平的消费与效用的统计学显著和有意义的改善相关。对于有终身或当前 AUD 的个体,从高、中、低风险水平禁欲与效用显著且有意义地恶化相关。
较高的酒精消费风险水平似乎与一般人群和有酒精使用障碍史的个体的健康指数得分较低相关,这意味着较高的酒精消费与较差的健康相关生活质量相关。