Department of Forensic Medicine, Guizhou Medical University, Guiyang, China.
Guiyang Judicial Expertise Center of Public Security, Guiyang, China.
Mol Genet Genomic Med. 2021 Feb;9(2):e1572. doi: 10.1002/mgg3.1572. Epub 2021 Jan 15.
Male-specifically inherited Y-STRs have been widely used in population genetics and forensic investigations.
We genotyped and analyzed Y chromosome haplotypes of 408 unrelated Tibeto-Burman-speaking Yi male individuals from Guizhou using Goldeneye Y-PLUS kit. Population comparisons between the Guizhou Yi and 67 reference groups were performed via the AMOVA, MDS, and phylogenetic relationship reconstruction.
A total of 389 alleles and 396 haplotypes could be detected, and the allelic frequencies ranged from 0.0025 to 0.9875. The haplotype diversity, random match probability, and discrimination capacity values were 0.9999, 0.0026, and 0.9900, respectively. The gene diversity (GD) of 36 Y-STR loci in the studied group ranged from 0.0248 (DYS645) to 0.9601 (DYS385a/b). Our newly genotyped Yi samples show a close affinity with other Tibeto-Burman speaking groups in China and Southeast Asia.
The population stratification was almost consistent with the geographic distribution and language-family, both among Chinese and worldwide ethnic groups. Our data may provide useful information for paternal lineage in the forensic application and population genetics, as well as evidence for archaeological and historical research.
男性特异性遗传的 Y-STR 已广泛应用于群体遗传学和法医学研究。
我们使用 Goldeneye Y-PLUS 试剂盒对来自贵州的 408 名无亲缘关系的藏族-缅甸语系彝族男性个体的 Y 染色体单倍型进行了基因分型和分析。通过 AMOVA、MDS 和系统发育关系重建，对贵州彝族群体与 67 个参考群体进行了群体比较。
共检测到 389 个等位基因和 396 个单倍型，等位基因频率范围为 0.0025 至 0.9875。单倍型多样性、随机匹配概率和鉴别能力值分别为 0.9999、0.0026 和 0.9900。研究组中 36 个 Y-STR 位点的基因多样性（GD）范围为 0.0248（DYS645）至 0.9601（DYS385a/b）。我们新分型的彝族样本与中国和东南亚其他藏缅语系群体具有密切的亲缘关系。
人群分层与地理分布和语言家族几乎一致，无论是在中国还是在全球族群中。我们的数据可能为法医学应用和群体遗传学中的父系血统提供有用的信息，并为考古学和历史学研究提供证据。
