Department of General, Visceral & Transplant Surgery, Comprehensive Cancer Center, University of Tübingen, Hoppe-Seyler-Strasse 3, Tübingen 72076, Germany.
Department of Pharmacy, Biopharmaceutics & Pharmaceutical Technology, Saarland University, Saarbrücken 66123, Germany.
Nanomedicine (Lond). 2021 Jan;16(2):109-120. doi: 10.2217/nnm-2020-0373. Epub 2021 Jan 15.
To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders . The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Positively charged CUR-PLGA-NPs increased depth of tissue penetration by 81.5% and tissue concentration by 80%. Electrostatic precipitation further improved the uptake of positively charged CUR-PLGA-NPs by 41.8%. The combination of positive charge and electrostatic precipitation have significant potential to improve tissue uptake of nanoparticles during intraperitoneal chemotherapy.
研究姜黄素负载聚乳酸-共-羟基乙酸纳米粒（CUR-PLGA-NPs）单独应用和电沉积法在提高腹腔内压力雾化化疗（PIPAC）期间组织摄取中的作用。正、负电荷 CUR-PLGA-NPs 被作为 PIPAC 递送至倒置的牛膀胱内。在附加使用静电沉淀的情况下重复该实验进行腹腔内压力雾化化疗（静电 PIPAC）。正电荷 CUR-PLGA-NPs 使组织穿透深度增加了 81.5%，组织浓度增加了 80%。静电沉淀进一步使正电荷 CUR-PLGA-NPs 的摄取增加了 41.8%。正电荷和静电沉淀的结合具有显著提高腹腔化疗期间纳米颗粒组织摄取的潜力。
