一项比较高选择性迷走神经切断术与扩大高选择性迷走神经切断术治疗十二指肠溃疡患者的前瞻性随机研究。

A prospective, randomized study comparing highly selective vagotomy and extended highly selective vagotomy in patients with duodenal ulcer.

作者信息

Braghetto I, Csendes A, Lazo M, Rebolledo P, Díaz A, Bardavid A, Bahamonde A, Thomet G

机构信息

Department of Surgery, San José Hospital, Santiago.

出版信息

Am J Surg. 1988 Mar;155(3):443-6. doi: 10.1016/s0002-9610(88)80110-7.

DOI:10.1016/s0002-9610(88)80110-7

PMID:3344909

Abstract

The recurrence rate of duodenal ulcer after highly selective vagotomy is nearly 10 percent. To diminish this percentage, extended highly selective vagotomy with sectioning the gastroepiploic nerves has been proposed in order to reduce postoperative gastric acid secretion. We have prospectively compared the decrease in gastric acid secretion through measurement of basal acid output, maximal acid output, and peak acid output in patients who underwent highly selective vagotomy or extended highly selective vagotomy. No significant differences in postoperative gastric acid secretion were found and, therefore, no changes in the probability of postoperative recurrence of duodenal ulcer were seen.

摘要

高选择性迷走神经切断术后十二指肠溃疡的复发率接近10%。为降低这一比例，有人提出行扩大高选择性迷走神经切断术，切断胃网膜神经，以减少术后胃酸分泌。我们前瞻性地比较了接受高选择性迷走神经切断术或扩大高选择性迷走神经切断术患者的基础胃酸分泌量、最大胃酸分泌量和高峰胃酸分泌量的下降情况。术后胃酸分泌未见显著差异，因此，十二指肠溃疡术后复发的概率也未见变化。