Kihl B, Olbe L
Gut. 1980 Dec;21(12):1056-61. doi: 10.1136/gut.21.12.1056.
In seven duodenal ulcer patients the effect of intraduodenal infusion of 20 ml oleic acid on submaximal gastric acid secretion stimulation by a continuous pentagastrin infusion was evaluated before and after proximal gastric vagotomy. In the control tests 20 ml of saline was given. Before vagotomy, oleic acid evoked a significant inhibition of gastric acid secretion of 25% compared with the controls. This inhibition was abolished after proximal gastric vagotomy. The difference in inhibition before and after vagotomy was significant (P=0.01). It is concluded that the vagus nerve in man plays a decisive role in duodenal fat inhibition of gastric acid secretion.
在7例十二指肠溃疡患者中，评估了近端胃迷走神经切断术前和术后十二指肠内注入20毫升油酸对持续静脉输注五肽胃泌素引起的次最大胃酸分泌刺激的影响。对照试验中给予20毫升生理盐水。迷走神经切断术前，与对照组相比，油酸引起胃酸分泌显著抑制25%。近端胃迷走神经切断术后这种抑制作用消失。迷走神经切断术前和术后抑制作用的差异具有显著性（P = 0.01）。得出的结论是，人类迷走神经在十二指肠脂肪对胃酸分泌的抑制中起决定性作用。
