壬二酸通过增加脂肪酸去饱和作用促进秀丽隐杆线虫在低温下的寿命。
Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation.
机构信息
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China.
Department of Food Science, Purdue University, West Lafayette, Indiana, 47907, USA.
出版信息
Pharm Res. 2021 Jan;38(1):15-26. doi: 10.1007/s11095-020-02975-w. Epub 2021 Jan 15.
PURPOSE
Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recently, AzA is shown to reduce high-fat diet-induced adiposity in animals. However, its physiological role in lipid metabolism and aging in various environmental stresses is unknown.
METHODS AND RESULTS
Using C. elegans as an invertebrate animal model, we demonstrate that AzA suppresses fat accumulation with no effect on lifespan at normal temperatures. Moreover, AzA promotes lifespan at low temperatures by elevation of unsaturated long-chain fatty acids and expression of genes in fatty acid desaturation. We further find that genes encoding fatty acid desaturases such as fat-1, fat-5, fat-6, and fat-7 are crucial for the lifespan-extending effect of AzA at low temperature.
CONCLUSIONS
Taken together, our results suggest that AzA promotes adaption to low temperature in C. elegans via shifting fatty acid profile to unsaturated long-chain fatty acids.
目的
壬二酸（AzA）是一种天然存在于各种谷物中的二羧酸，具有抗炎和抗氧化特性。最近，AzA 被证明可以减少动物的高脂肪饮食诱导的肥胖。然而，其在各种环境应激下的脂质代谢和衰老中的生理作用尚不清楚。
方法和结果
我们使用秀丽隐杆线虫作为无脊椎动物模型，证明 AzA 在正常温度下抑制脂肪积累，对寿命没有影响。此外，AzA 通过提高不饱和长链脂肪酸和脂肪酸去饱和基因的表达来延长低温下的寿命。我们进一步发现，编码脂肪酸去饱和酶的基因，如 fat-1、fat-5、fat-6 和 fat-7，对于 AzA 在低温下延长寿命的作用至关重要。
结论
综上所述，我们的结果表明，AzA 通过将脂肪酸谱转移到不饱和长链脂肪酸来促进秀丽隐杆线虫对低温的适应。
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