School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China.
J Fluoresc. 2021 Mar;31(2):501-507. doi: 10.1007/s10895-021-02682-8. Epub 2021 Jan 15.
Increasing acidity is an effective method for bacterial inactivation by inhibiting the synthesis of intracellular proteins at low pH. Photo-driven proton release probe can be used for the measurement of proton in hydrophobic condition. To develop fluorescent proton donor, two boron dipyrromethene derivatives (BDP-S and BDP-S2) were characterized by spectroscopic methods. Irradiation of BDP-S by white LED light resulted in efficient generation of acidic species with changes of fluorescence emission. The linear relationship between the pH value and the fluorescence intensity of BDP-S was obtained, indicating that BDP-S is a fluorescent visual proton donor. Light-induced antibacterial results indicate that BDP-S can significantly inhibit the growth of E. coli. The results prove that BDP-S is a very promising photoacid sterilant.
酸度增加是通过在低 pH 值下抑制细胞内蛋白质合成来有效灭活细菌的方法。光致质子释放探针可用于疏水环境中质子的测量。为了开发荧光质子供体，我们通过光谱法对两个硼二吡咯甲烷衍生物（BDP-S 和 BDP-S2）进行了表征。BDP-S 在白色 LED 光照射下可有效生成酸性物质，同时荧光发射发生变化。BDP-S 的 pH 值与荧光强度之间存在线性关系，表明 BDP-S 是一种荧光可视质子供体。光诱导的抑菌结果表明，BDP-S 能显著抑制大肠杆菌的生长。这些结果证明 BDP-S 是一种很有前途的光酸杀菌剂。
