Macatee Richard J, Burkhouse Katie L, Afshar Kaveh, Schroth Christopher, Aase Darren M, Greenstein Justin E, Proescher Eric, Phan K Luan
Department of Psychological Sciences, Auburn University, United States of America.
Department of Psychiatry, University of Illinois at Chicago, United States of America.
Int J Psychophysiol. 2021 Mar;161:13-26. doi: 10.1016/j.ijpsycho.2021.01.001. Epub 2021 Jan 12.
Trauma exposure is prevalent, associated with multiple forms of psychopathology, and thought to alter the neurobiological substrates of threat processing. The late positive potential (LPP) is an event-related potential (ERP) that may be a clinically useful probe of the neurobiology of threat processing. Despite evidence that combat-exposed veterans exhibit aberrant threat modulation of the LPP, no studies to date have tested the psychometric properties of the LPP in combat trauma-exposed, symptomatic veterans. The primary aim of the current study was to evaluate the reliability (internal consistency, retest reliability) and convergent validity of LPP modulation by threatening faces and scenes in two common tasks among combat-exposed veterans. Participants included 82 combat-exposed veterans who completed face-matching and emotion regulation tasks during EEG recording at baseline and twelve weeks. Internal consistencies of the early LPP time windows (<1000 ms) were acceptable in both tasks, whereas they were poor in late time windows (>1000 ms). Twelve-week retest reliabilities were fair for the early window LPPs to threatening scenes and fear faces, as well as in the late time window for fear faces. Reliabilities were better for individual condition compared to difference scores. Finally, LPPs modulated by threatening scenes and faces were unrelated. Together, these results suggest that the LPPs to threatening scenes and faces reflect distinct forms of threat processing in combat-exposed veterans, and their reliabilities for the early window indicate potential clinical utility in this population.
创伤暴露很常见，与多种形式的精神病理学相关，并且被认为会改变威胁处理的神经生物学基础。晚期正电位（LPP）是一种事件相关电位（ERP），可能是威胁处理神经生物学的一种临床上有用的探测指标。尽管有证据表明经历过战斗的退伍军人表现出LPP的异常威胁调节，但迄今为止，尚无研究测试LPP在经历战斗创伤且有症状的退伍军人中的心理测量特性。本研究的主要目的是评估在经历过战斗的退伍军人中，在两项常见任务中，通过威胁性面孔和场景对LPP调节的可靠性（内部一致性、重测可靠性）和收敛效度。参与者包括82名经历过战斗的退伍军人，他们在基线和12周时进行脑电图记录期间完成了面部匹配和情绪调节任务。在两项任务中，早期LPP时间窗口（<1000毫秒）的内部一致性均可接受，而在晚期时间窗口（>1000毫秒）则较差。对于早期窗口LPP对威胁场景和恐惧面孔的反应，以及晚期时间窗口对恐惧面孔的反应，12周重测可靠性一般。与差异分数相比，个体条件的可靠性更好。最后，由威胁场景和面孔调节的LPPs不相关。总之，这些结果表明，对威胁场景和面孔的LPPs反映了经历过战斗的退伍军人中不同形式的威胁处理，并且它们在早期窗口的可靠性表明了在该人群中的潜在临床效用。
