COVID-19：疾病，还是非疾病？这是个问题。关键在于剂量！
COVID-19: disease, or no disease? - that is the question. It's the dose stupid!
机构信息
Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City, PO Manauli Mohali, 140306, Punjab, India.
Biomedical & Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, 37996-0845, USA.
出版信息
Microbes Infect. 2021 Jan-Feb;23(1):104779. doi: 10.1016/j.micinf.2021.104779. Epub 2021 Jan 12.
The COVID-19 pandemic has raised many issues not the least of which is the reason for its high variability in consequences to the infected person. In this opinion letter, we advocate that the dose and presentation of the infecting virus is a major factor that affects whether the outcome is subclinical, tissue damaging or even lethal following infection. We briefly describe the known effects of virus dose on the course COVID-19 and discuss practical maneuvers as well as largely untested procedures that can raise the threshold dose needed to break through barriers of resistance.
新冠疫情提出了许多问题，其中最值得关注的是其对感染者的后果存在高度变异性的原因。在这封观点信中，我们主张，感染病毒的剂量和形式是影响感染后结果是无症状、组织损伤还是致命的主要因素。我们简要描述了已知的病毒剂量对新冠病毒病程的影响，并讨论了一些可行的手段以及尚未广泛验证的方法，这些方法可以提高突破耐药屏障所需的阈值剂量。
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