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The COMT gene rs4680 polymorphism moderates the relationship between adult ADHD symptoms and executive dysfunction.

作者信息

Liu Jianbo, Zhang Tingting, Mo Yanzi, Gong Jingbo

机构信息

Department of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Mental Health Center, School of Mental Health, Shenzhen University, Shenzhen, China.

Department of Student Affairs, Hunan University of Technology, Zhuzhou, Hunan, China.

出版信息

Asian J Psychiatr. 2021 Feb;56:102546. doi: 10.1016/j.ajp.2021.102546. Epub 2021 Jan 11.

DOI:10.1016/j.ajp.2021.102546
PMID:33450700
Abstract
摘要

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The COMT gene rs4680 polymorphism moderates the relationship between adult ADHD symptoms and executive dysfunction.儿茶酚-O-甲基转移酶（COMT）基因rs4680多态性调节成人注意力缺陷多动障碍（ADHD）症状与执行功能障碍之间的关系。
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[Association analysis between attention-deficit hyperactivity disorder and Val158Met polymorphism of catechol-O-methyltransferase gene].注意缺陷多动障碍与儿茶酚-O-甲基转移酶基因Val158Met多态性的关联分析
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Catechol-O-methyltransferase polymorphism is associated with the cortico-cerebellar functional connectivity of executive function in children with attention-deficit/hyperactivity disorder.儿茶酚-O-甲基转移酶多态性与注意缺陷多动障碍儿童执行功能的皮质-小脑功能连接有关。
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Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.注意缺陷多动障碍表型受儿茶酚-O-甲基转移酶功能变体的影响。
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Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents.青少年男性违法者中，儿茶酚-O-甲基转移酶Val 158 Met多态性的变异与品行障碍和多动症症状相关。
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