Faculty of Heath Sciences, School of Behavioural and Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia.
Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Nutrients. 2022 Mar 25;14(7):1379. doi: 10.3390/nu14071379.
Omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) are critical for cell membrane structure and function. Human beings have a limited ability to synthesise docosahexaenoic acid (DHA), the main n-3 LCPUFA required for neurological development. Inadequate levels of n-3 LCPUFA can affect the dopaminergic system in the brain and, when combined with genetic and other factors, increase the risk of developing aggression, inattention and impulse-control disorders. In this study, male prisoners were administered questionnaires assessing aggressive behaviour and executive functions. Participants also produced blood sampling for the measurement of the Omega-3 Index and the genotyping of dopaminergic genetic variants. Significant associations were found between functional genetic polymorphism in rs1611115 and verbal aggression and between rs4274224 and executive functions. However, the Omega-3 Index was not significantly associated with the tested dopaminergic polymorphisms. Although previous interactions between specific genotypes and n-3 LCPUFA were previously reported, they remain limited and poorly understood. We did not find any association between n-3 LCPUFA and dopaminergic polymorphisms in adult male prisoners; however, we confirmed the importance of genetic predisposition for dopaminergic genes ( and ) in aggressive behaviour, memory dysfunction and attention-deficit disorder.
ω-3 长链多不饱和脂肪酸（n-3 LCPUFA）对于细胞膜的结构和功能至关重要。人类合成二十二碳六烯酸（DHA）的能力有限，而 DHA 是神经发育所必需的主要 n-3 LCPUFA。n-3 LCPUFA 水平不足会影响大脑中的多巴胺能系统，并且在与遗传和其他因素结合时，会增加患攻击性、注意力不集中和冲动控制障碍的风险。在这项研究中，男性囚犯接受了评估攻击性行为和执行功能的问卷。参与者还进行了采血，以测量 Omega-3 指数和多巴胺能遗传变异的基因分型。在 rs1611115 和 rs4274224 中的功能性遗传多态性与言语攻击性之间以及在 rs4274224 与执行功能之间发现了显著的关联。然而，Omega-3 指数与测试的多巴胺能多态性没有显著关联。尽管之前已经报道了特定基因型和 n-3 LCPUFA 之间的相互作用，但它们仍然有限且理解不足。我们没有发现 n-3 LCPUFA 与成年男性囚犯中的多巴胺能多态性之间存在任何关联；然而，我们证实了多巴胺能基因（和）的遗传易感性对攻击性行为、记忆功能障碍和注意力缺陷障碍的重要性。
