de Groot Theun, Janssen Tom, Faro Dirk, Cremers Niels A J, Chowdhary Anuradha, Meis Jacques F
Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital (CWZ), 6532 SZ Nijmegen, The Netherlands.
Triticum Exploitatie BV, Sleperweg 44, 6222 NK Maastricht, The Netherlands.
J Fungi (Basel). 2021 Jan 13;7(1):50. doi: 10.3390/jof7010050.
is a pathogenic yeast causing outbreaks in intensive care units with high mortality rates. The treatment of colonization is challenging due to high resistance rates. A potential alternative antifungal treatment is medical-grade honey. In this study the susceptibility of and other species to the medical-grade honey-based formulation L-Mesitran Soft was investigated. The medical-grade honey formulation reduced the growth of and other species in a dose-dependent manner. This inhibition was not only due to the honey component, as treatment with an identical concentration of this component only was less effective and even stimulated the growth of and , supporting the interpretation that supplements in the medical-grade honey formulation enhanced the antimicrobial activity. Increasing the concentration of the honey component to 40%, as is also present in an undiluted medical-grade honey formulation, lead to a 1- to 4-log inhibition of all species. Unprocessed local honey reduced the growth of nearly all species more strongly than medical-grade honey. ' susceptibility to the medical-grade honey formulation did not depend on geographic origin or resistance profile, although the multiresistant isolates tended to be more susceptible. Altogether, medical-grade honey formulation has a strong antifungal activity against and other species. Future studies should demonstrate whether the treatment of open wounds or skin colonized with is feasible and effective in the clinical setting.
是一种致病性酵母,可在重症监护病房引发疫情,死亡率很高。由于耐药率高,治疗其定植具有挑战性。医用级蜂蜜是一种潜在的替代抗真菌治疗方法。在本研究中,研究了[具体菌种名称]和其他[具体菌种名称]对基于医用级蜂蜜的制剂L-Mesitran Soft的敏感性。医用级蜂蜜制剂以剂量依赖的方式减少了[具体菌种名称]和其他[具体菌种名称]的生长。这种抑制作用不仅归因于蜂蜜成分,因为仅用相同浓度的该成分进行处理效果较差,甚至还刺激了[具体菌种名称]和[具体菌种名称]的生长,这支持了医用级蜂蜜制剂中的添加剂增强了抗菌活性的解释。将蜂蜜成分的浓度提高到40%(未稀释的医用级蜂蜜制剂中也存在该浓度),导致所有[具体菌种名称]的生长受到1至4个对数级的抑制。未经加工的本地蜂蜜比医用级蜂蜜更能强烈地抑制几乎所有[具体菌种名称]的生长。[具体菌种名称]对医用级蜂蜜制剂的敏感性并不取决于地理来源或耐药谱,尽管多重耐药菌株往往更易受到影响。总之,医用级蜂蜜制剂对[具体菌种名称]和其他[具体菌种名称]具有很强的抗真菌活性。未来的研究应证明,在临床环境中,治疗开放性伤口或被[具体菌种名称]定植的皮肤是否可行且有效。