Grinn-Gofroń Agnieszka, Kołodziejczak Maciej, Hrynkiewicz Rafał, Lewandowski Filip, Bębnowska Dominika, Adamski Cezary, Niedźwiedzka-Rystwej Paulina
Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland.
Center for Experimental Immunology and Immunobiology in Infectious Diseases and Cancer, University of Szczecin, 71-412 Szczecin, Poland.
Pathogens. 2025 Aug 6;14(8):780. doi: 10.3390/pathogens14080780.
Bee products, in particular honey, propolis and bee venom, are of growing scientific interest due to their broad spectrum of antimicrobial activity. In the face of increasing antibiotic resistance and the limitations of conventional therapies, natural bee-derived substances offer a promising alternative or support for the treatment of infections. This paper summarizes the current state of knowledge on the chemical composition, biological properties and antimicrobial activity of key bee products. The main mechanisms of action of honey, propolis and bee venom are presented, and their potential applications in the prevention and treatment of bacterial, viral and fungal infections are discussed. Data on their synergy with conventional drugs and prospects for use in medicine and pharmacology are also included. The available findings suggest that, with appropriate standardization and further preclinical and clinical analyses, bee products could become an effective support for the treatment of infections, especially those caused by pathogens resistant to standard therapies.
蜂产品,尤其是蜂蜜、蜂胶和蜂毒,因其广泛的抗菌活性而受到越来越多的科学关注。面对日益增加的抗生素耐药性以及传统疗法的局限性,天然蜂源物质为感染治疗提供了一种有前景的替代方案或支持。本文总结了关于关键蜂产品的化学成分、生物学特性和抗菌活性的当前知识状态。介绍了蜂蜜、蜂胶和蜂毒的主要作用机制,并讨论了它们在预防和治疗细菌、病毒及真菌感染方面的潜在应用。还包括了它们与传统药物协同作用的数据以及在医学和药理学中的应用前景。现有研究结果表明,经过适当的标准化以及进一步的临床前和临床分析,蜂产品有望成为治疗感染的有效辅助手段,尤其是针对那些对标准疗法耐药的病原体所引起的感染。