Department of Translational and Precision Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, Italy.
Int J Mol Sci. 2021 Jan 13;22(2):742. doi: 10.3390/ijms22020742.
Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function. Alteration of adipose tissue functions (also called adiposopathy) is considered the main inducer of metabolic syndrome (MS) and its related complications. In this review, we intended to analyze available evidence derived from experimental and human investigations highlighting the contribution of ANGPTLs in the regulation of adipocyte metabolism, as well as their potential role in common cardiometabolic alterations associated with adiposopathy. We finally propose a model of ANGPTLs-based adipose tissue dysfunction, possibly linking abnormalities in the angiopoietins to the induction of adiposopathy and its related disorders.
血管生成素样蛋白，即 ANGPTL3-4-8，被认为是脂质代谢的调节剂。然而，最近的证据表明它们参与了脂肪组织功能的调节。脂肪组织功能的改变（也称为脂肪病）被认为是代谢综合征（MS）及其相关并发症的主要诱因。在这篇综述中，我们旨在分析来自实验和人类研究的现有证据，强调 ANGPTLs 在调节脂肪细胞代谢中的作用，以及它们在与脂肪病相关的常见心血管代谢改变中的潜在作用。最后，我们提出了一个基于 ANGPTLs 的脂肪组织功能障碍模型，可能将血管生成素的异常与脂肪病及其相关疾病的诱导联系起来。
