Ferenc Katarzyna, Jarmakiewicz-Czaja Sara, Sokal-Dembowska Aneta, Stasik Katarzyna, Filip Rafał
Institute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, Poland.
Institute of Health Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland.
Curr Issues Mol Biol. 2024 Jun 29;46(7):6690-6709. doi: 10.3390/cimb46070399.
Currently, steatohepatitis has been designated as metabolic dysfunction-associated steatohepatitis (MASLD). MASLD risk factors mainly include metabolic disorders but can also include genetic, epigenetic, and environmental factors. Disease entities such as obesity, diabetes, cardiovascular disease, and MASLD share similar pathomechanisms and risk factors. Moreover, a bidirectional relationship is observed between the occurrence of certain chronic diseases and MASLD. These conditions represent a global public health problem that is responsible for poor quality of life and high mortality. It seems that paying holistic attention to these problems will not only help increase the chances of reducing the incidence of these diseases but also assist in the prevention, treatment, and support of patients.
目前，脂肪性肝炎已被指定为代谢功能障碍相关脂肪性肝炎（MASLD）。MASLD的风险因素主要包括代谢紊乱，但也可能包括遗传、表观遗传和环境因素。肥胖、糖尿病、心血管疾病和MASLD等疾病实体具有相似的发病机制和风险因素。此外，在某些慢性病的发生与MASLD之间观察到双向关系。这些情况代表了一个全球性的公共卫生问题，导致生活质量低下和高死亡率。似乎全面关注这些问题不仅有助于增加降低这些疾病发病率的机会，还能协助对患者的预防、治疗和支持。
