Muraki T, Tokunaga Y, Makino T
Endocrinol Jpn. 1977 Jun;24(3):313-5. doi: 10.1507/endocrj1954.24.313.
Proestrus surges of serum LH, FSH and prolactin (PRL) were significantly reduced when morphine HCl (50 and 10 mg/kg) was administered to 4-day cycling rats just prior to the proestrous critical period. The inhibitory effect of morphine was reversed by naloxone, a morphine antagonist, at the dose which had no effect on the proestrus surges of serum LH, FSH or PRL. The hypothalamic LH-RF content of proestrous rats at 1800 hr (during the proestrus surge) was not significantly different from that at 1400 hr (before the surge) and was not affected by pretreatment with morphine or naloxone. Our results suggest that naloxone reverses the anti-ovulatory effect of morphine by antagonizing the inhibitory effect of morphine on preovulatory surges of gonadotropins or PRL.
在发情前期关键期之前，给处于4天发情周期的大鼠注射盐酸吗啡（50毫克/千克和10毫克/千克），血清促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素（PRL）的发情前期激增显著降低。吗啡拮抗剂纳洛酮以对血清LH、FSH或PRL的发情前期激增无影响的剂量使用时，可逆转吗啡的抑制作用。发情前期大鼠在1800时（发情前期激增期间）的下丘脑促黄体生成素释放因子（LH-RF）含量与1400时（激增前）无显著差异，且不受吗啡或纳洛酮预处理的影响。我们的结果表明，纳洛酮通过拮抗吗啡对促性腺激素或PRL排卵前激增的抑制作用，逆转了吗啡的抗排卵作用。
