Fuchs H A, Callahan L F, Kaye J J, Brooks R H, Nance E P, Pincus T
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Arthritis Rheum. 1988 Jan;31(1):44-51. doi: 10.1002/art.1780310107.
Radiographic and physical joint count findings of the hands and wrists of 148 patients with rheumatoid arthritis (RA) were analyzed in a cross-sectional study. Quantitative radiographic scores for joint space narrowing, erosion, and malalignment were correlated highly with joint count scores for limitation of motion and deformity, and were correlated at considerably lower levels with joint swelling scores. Radiographic scores, however, were not correlated at all with joint count tenderness scores. That 2 of the most widely used indices of RA disease activity, radiographic erosion scores and joint count scores for tenderness, were independent of one another at a selected timepoint, should be considered in the design of clinical trials and long-term observation of patients with RA.
在一项横断面研究中，分析了148例类风湿关节炎（RA）患者手部和腕部的影像学及体格检查关节计数结果。关节间隙变窄、侵蚀和排列不齐的定量影像学评分与运动受限和畸形的关节计数评分高度相关，而与关节肿胀评分的相关性则低得多。然而，影像学评分与关节计数压痛评分完全不相关。在设计RA患者的临床试验和长期观察时，应考虑到RA疾病活动最常用的两个指标，即影像学侵蚀评分和压痛关节计数评分，在选定的时间点相互独立。
