Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Arnold-Heller-Str. 3, Haus C, 24105, Kiel, Germany.
Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), Marchioninistraße 25, 81377, Munich, Germany.
Commun Biol. 2021 Jan 15;4(1):73. doi: 10.1038/s42003-020-01591-z.
Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.
中枢神经系统（CNS）受累仍然是急性淋巴细胞白血病（ALL）诊断和治疗的一个挑战。在这项研究中，我们发现 CD79a（也称为 Igα），前 B 细胞受体（preBCR）的信号成分，与 B 细胞前体（BCP）-ALL 患者的 CNS 浸润和复发相关。此外，我们还表明，下调 CD79a 会阻碍白血病细胞在不同的小鼠异种移植模型中的植入，特别是在 CNS 中。
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