School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.
Beijing No. 2 Middle School-Chaoyang, Beijing, 100025, China.
Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9345-9350. doi: 10.1002/anie.202015564. Epub 2021 Mar 12.
The scaffolded DNA origami approach and the scaffold-free LEGO approach both demonstrate an extraordinary self-assembly capability for constructing all kinds of complex DNA nanostructures. Combining the construction elements of the two approaches, we introduce a hybrid framework to build wireframe structures in this study. A collection of two-dimensional (2D) and three-dimensional (3D) wireframe structures are presented to showcase the simple and versatile design. Our development reveals more of the ever-expanding design space of structural DNA nanotechnology.
折纸 DNA 方法和无支架 LEGO 方法都展示了构建各种复杂 DNA 纳米结构的非凡自组装能力。本研究结合了两种方法的构建元件，引入了一种混合框架来构建线框结构。展示了一系列二维（2D）和三维（3D）线框结构，以展示其简单而通用的设计。我们的开发揭示了结构 DNA 纳米技术的设计空间不断扩大。
