基于框架 DNA 的可编程纳米结构在生物传感中的应用
Programmable Nanostructures Based on Framework-DNA for Applications in Biosensing.
机构信息
School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
出版信息
Sensors (Basel). 2023 Mar 21;23(6):3313. doi: 10.3390/s23063313.
DNA has been actively utilized as bricks to construct exquisite nanostructures due to their unparalleled programmability. Particularly, nanostructures based on framework DNA (F-DNA) with controllable size, tailorable functionality, and precise addressability hold excellent promise for molecular biology studies and versatile tools for biosensor applications. In this review, we provide an overview of the current development of F-DNA-enabled biosensors. Firstly, we summarize the design and working principle of F-DNA-based nanodevices. Then, recent advances in their use in different kinds of target sensing with effectiveness have been exhibited. Finally, we envision potential perspectives on the future opportunities and challenges of biosensing platforms.
由于其无与伦比的可编程性，DNA 一直被积极用作构建精致纳米结构的“砖块”。特别是，基于具有可控尺寸、可定制功能和精确寻址性的骨架 DNA（F-DNA）的纳米结构，为分子生物学研究提供了极好的前景，也是生物传感器应用的多功能工具。在这篇综述中，我们概述了基于 F-DNA 的生物传感器的最新发展。首先，我们总结了基于 F-DNA 的纳米器件的设计和工作原理。然后，展示了它们在不同种类的目标传感中有效性的最新进展。最后，我们展望了生物传感平台未来的机遇和挑战。
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