文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

基于框架 DNA 的可编程纳米结构在生物传感中的应用

Programmable Nanostructures Based on Framework-DNA for Applications in Biosensing.

机构信息

School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.

State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.

出版信息

Sensors (Basel). 2023 Mar 21;23(6):3313. doi: 10.3390/s23063313.

DOI:10.3390/s23063313
PMID:36992023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10051322/
Abstract

DNA has been actively utilized as bricks to construct exquisite nanostructures due to their unparalleled programmability. Particularly, nanostructures based on framework DNA (F-DNA) with controllable size, tailorable functionality, and precise addressability hold excellent promise for molecular biology studies and versatile tools for biosensor applications. In this review, we provide an overview of the current development of F-DNA-enabled biosensors. Firstly, we summarize the design and working principle of F-DNA-based nanodevices. Then, recent advances in their use in different kinds of target sensing with effectiveness have been exhibited. Finally, we envision potential perspectives on the future opportunities and challenges of biosensing platforms.

摘要

由于其无与伦比的可编程性，DNA 一直被积极用作构建精致纳米结构的“砖块”。特别是，基于具有可控尺寸、可定制功能和精确寻址性的骨架 DNA（F-DNA）的纳米结构，为分子生物学研究提供了极好的前景，也是生物传感器应用的多功能工具。在这篇综述中，我们概述了基于 F-DNA 的生物传感器的最新发展。首先，我们总结了基于 F-DNA 的纳米器件的设计和工作原理。然后，展示了它们在不同种类的目标传感中有效性的最新进展。最后，我们展望了生物传感平台未来的机遇和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/9f07a8c70275/sensors-23-03313-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/ec9c3c01a9f0/sensors-23-03313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/2762b4386b8c/sensors-23-03313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/2eb99be4f76b/sensors-23-03313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/162e98124c3c/sensors-23-03313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/35f186b7e2e1/sensors-23-03313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/9f07a8c70275/sensors-23-03313-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/ec9c3c01a9f0/sensors-23-03313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/2762b4386b8c/sensors-23-03313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/2eb99be4f76b/sensors-23-03313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/162e98124c3c/sensors-23-03313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/35f186b7e2e1/sensors-23-03313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e97/10051322/9f07a8c70275/sensors-23-03313-g006.jpg

相似文献

[1]
Programmable Nanostructures Based on Framework-DNA for Applications in Biosensing.

Sensors (Basel). 2023-3-21

[2]
Framework-Nucleic-Acid-Enabled Biosensor Development.

ACS Sens. 2018-5-14

[3]
DNA Nanotechnology-Based Biosensors and Therapeutics.

Adv Healthc Mater. 2021-8

[4]
Aptamer-Functionalized DNA Nanostructures for Biological Applications.

Top Curr Chem (Cham). 2020-2-7

[5]
DNA Walkers for Biosensing Development.

Adv Sci (Weinh). 2022-6

[6]
Rational Design of Framework Nucleic Acids for Bioanalytical Applications.

Chempluschem. 2019-4-29

[7]
DNA nanotechnology-enabled biosensors.

Biosens Bioelectron. 2015-7-6

[8]
DNA Nanotweezers for Biosensing Applications: Recent Advances and Future Prospects.

ACS Sens. 2022-1-28

[9]
The combination of DNA nanostructures and materials for highly sensitive electrochemical detection.

Bioelectrochemistry. 2024-6

[10]
DNA framework-engineered electrochemical biosensors.

Sci China Life Sci. 2020-4-3

引用本文的文献

[1]
Hsa-circVIM regulates breast cancer tumor progression and tamoxifen sensitivity by sponging miR-1294 in hormone receptor-positive breast cancer cells.

Discov Oncol. 2025-5-8

[2]
Progressive cancer targeting by programmable aptamer-tethered nanostructures.

MedComm (2020). 2024-10-20

[3]
Special Issue "Feature Papers in Biosensors Section 2022".

Sensors (Basel). 2023-4-3

本文引用的文献

[1]
DNA tetrahedron-besieged primer and DNAzyme-activated programmatic RCA for low-background electrochemical detection of ochratoxin A.

Anal Chim Acta. 2023-2-15

[2]
DNA Tetrahedron-Based Valency Controlled Signal Probes for Tunable Protein Detection.

ACS Sens. 2023-1-27

[3]
Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer.

J Am Chem Soc. 2022-12-28

[4]
A novel cascade signal amplification strategy integrating CRISPR/Cas13a and branched hybridization chain reaction for ultra-sensitive and specific SERS detection of disease-related nucleic acids.

Biosens Bioelectron. 2023-1-1

[5]
Universal DNAzyme walkers-triggered CRISPR-Cas12a/Cas13a bioassay for the synchronous detection of two exosomal proteins and its application in intelligent diagnosis of cancer.

Biosens Bioelectron. 2023-1-1

[6]
Electrochemical Aptasensing of SARS-CoV-2 Based on Triangular Prism DNA Nanostructures and Dumbbell Hybridization Chain Reaction.

Anal Chem. 2022-10-25

[7]
Biomimetic 3D Recognition with 2D Flexible Nanoarchitectures for Ultrasensitive and Visual Extracellular Vesicle Detection.

Anal Chem. 2022-10-25

[8]
Non-autofluorescence Detection of H5N1 Virus Using Photochemical Aptamer Sensors Based on Persistent Luminescent Nanoparticles.

ACS Appl Mater Interfaces. 2022-10-19

[9]
DNA Zipper Mediated Membrane Fusion for Rapid Exosomal MiRNA Detection.

Anal Chem. 2022-9-27

[10]
Detection of Heavy Metal Ions by Ratiometric Photoelectric Sensor.

J Agric Food Chem. 2022-9-21

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索