Belenkaia Liliia V, Lazareva Lyudmila M, Walker Walidah, Lizneva Daria V, Suturina Larisa V
Department of Reproductive Health Protection, Scientific Center for Family Health and Human Reproduction, Irkutsk, Russia.
Research Administration Office, Augusta University, Augusta, GA, USA.
Minerva Ginecol. 2019 Jun;71(3):211-223. doi: 10.23736/S0026-4784.19.04404-6.
Polycystic ovarian syndrome (PCOS) is known as one of the most frequent endocrine diseases in women worldwide. However, this term does not completely capture the diversity of clinical signs associated with this syndrome e.g., menstrual irregularity and clinical features of androgen excess, which are though commonplace in women with PCOS, they are not included under the definition of PCOS, limited to polycystic ovarian morphology (PCOM). Utilizing the most globally accepted criterion used today in the diagnosis of PCOS, the authors of this article review and discuss the historical and current context of evidence as well as their limitations. This review addresses the phenotypic approach and age-dependent aspects of PCOS in adolescents, adult and peri/postmenopausal women, as presented in the NIH (1990, 2012), Rotterdam (2003), AE-PCOS Society (2006) consensuses and in the latest evidence-based international guideline (2018). Global data on the epidemiology of PCOS, including prevalence and distribution of polycystic ovarian syndrome phenotypes, is also analyzed in the article. Lastly, the authors discuss the importance and current need to perform more epidemiological studies focused on PCOS.
多囊卵巢综合征（PCOS）是全球女性中最常见的内分泌疾病之一。然而，这个术语并不能完全涵盖与该综合征相关的临床症状的多样性，例如月经不规律和雄激素过多的临床特征，尽管这些症状在PCOS女性中很常见，但它们并不包含在PCOS的定义范围内，PCOS的定义仅限于多囊卵巢形态（PCOM）。本文作者利用当今全球诊断PCOS最常用的标准，回顾并讨论了证据的历史和现状及其局限性。本综述探讨了PCOS在青少年、成年和围绝经期/绝经后女性中的表型方法和年龄相关方面，这些内容在NIH（1990年、2012年）、鹿特丹（2003年）、AE-PCOS协会（2006年）的共识以及最新的循证国际指南（2018年）中均有呈现。本文还分析了PCOS流行病学的全球数据，包括多囊卵巢综合征表型的患病率和分布情况。最后，作者讨论了开展更多聚焦于PCOS的流行病学研究的重要性和当前需求。
