North of Riyadh Dental Centre, Central Second Health Cluster, Riyadh, Saudi Arabia.
Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Oral Dis. 2022 Apr;28(3):657-669. doi: 10.1111/odi.13777. Epub 2021 Feb 2.
A complete understanding of oral mucositis (OM) is crucial to develop appropriate interventions to aid in the successful overall health outcome of paediatric patients undergoing haematopoietic stem cell transplantation (HSCT).
This study aimed at determining the prevalence and severity of OM and at identifying the predictive factors that might aggravate OM at one-week, two-week and three-week post-HSCT.
This retrospective, hospital-based study reviewed the medical records of 170 paediatric patients, summarising the patients' characteristics using descriptive statistics. Binary logistic regression was used to identify factors associated with the development of OM.
At one-week post-HSCT, 41% of 140 patients (n = 49) had developed OM, this was reduced at two-week (n = 36, 33%) and three-week (n = 13, 19%) post-HSCT. Univariate logistic regression revealed that patients with cancer (OR = 0.16, 95% CI = 0.05-0.54; p-value = .003) had a significantly lower prevalence of OM. Younger patients with an average age of 7.9 years old (OR = 0.85, 95% CI = 0.75-0.97; p-value = 0.013) and the presence of GvHD (OR = 2.37, 95% CI = 1.03-5.45, p-value = 0.042) were significantly related to a higher prevalence of OM. Multivariable logistic regression confirmed that the risk of OM is lower in patients with cancer compared to those with immunodeficiency syndromes or hereditary blood diseases (OR = 0.18, 95% CI = 0.04-0.77; p-value = .021).
This study identified a significantly lower prevalence of OM in patients with cancer compared to other conditions and that young recipients and those who developed GvHD were more likely to have OM.
全面了解口腔黏膜炎（OM）对于制定适当的干预措施以促进接受造血干细胞移植（HSCT）的儿科患者的整体健康结局至关重要。
本研究旨在确定 OM 的发生率和严重程度，并确定可能在 HSCT 后一周、两周和三周时加重 OM 的预测因素。
这是一项回顾性的基于医院的研究，对 170 名儿科患者的病历进行了审查，使用描述性统计对患者特征进行总结。采用二元逻辑回归分析确定与 OM 发生相关的因素。
在 HSCT 后一周时，140 名患者中有 41%（n=49）发生了 OM，在两周（n=36，33%）和三周（n=13，19%）时有所减少。单变量逻辑回归显示，患有癌症的患者（OR=0.16，95%CI=0.05-0.54；p 值=0.003）的 OM 发生率显著降低。年龄较小（平均年龄 7.9 岁）的患者（OR=0.85，95%CI=0.75-0.97；p 值=0.013）和存在 GvHD（OR=2.37，95%CI=1.03-5.45，p 值=0.042）的患者的 OM 发生率显著较高。多变量逻辑回归证实，与免疫缺陷综合征或遗传性血液疾病患者相比，癌症患者发生 OM 的风险较低（OR=0.18，95%CI=0.04-0.77；p 值=0.021）。
与其他疾病相比，癌症患者 OM 的发生率显著降低，年轻的受者和发生 GvHD 的患者更有可能发生 OM。
