Gao Xuan, Zhao Shengnan, Wang Shuting, Sun Yang, Gao Chengzhi
Peking University People's Hospital, Beijing, China.
Heliyon. 2024 May 10;10(10):e30998. doi: 10.1016/j.heliyon.2024.e30998. eCollection 2024 May 30.
This retrospective analysis aimed to evaluate the prevalence of periodontitis in patients undergoing hematopoietic stem cell transplantation, and investigate the effects of various periodontal statuses and risk factors on oral infection incidence.
Medical records of patients pre- and post-hematopoietic stem cell transplantation from June 2019 to October 2021were reviewed. The study examined the effort of different periodontal statuses on oral complications and infections in patients during transplantation.
Of 549 transplant patients studied, 363 had periodontitis. Patients with or without periodontitis showed significant differences in mean age, male proportion, and mucositis incidence during transplantation (P < 0.05). Bacteremia rates were slightly higher in patients with periodontitis, but not significant. Male proportion, age, and hospitalization duration significantly increased with advancing periodontitis stages. Only two patients experienced periodontal complications, that were effectively managed and did not interfere in the grafting process.
Periodontitis is prevalent in patients with hematopoietic diseases. Despite its association with oral mucositis, the occurrence of periodontal infection remains low and controllable.
本回顾性分析旨在评估接受造血干细胞移植患者的牙周炎患病率，并研究不同牙周状况和危险因素对口腔感染发生率的影响。
回顾了2019年6月至2021年10月期间造血干细胞移植患者移植前后的病历。该研究考察了不同牙周状况对移植期间患者口腔并发症和感染的影响。
在研究的549例移植患者中，363例患有牙周炎。有或无牙周炎的患者在移植期间的平均年龄、男性比例和黏膜炎发生率方面存在显著差异（P<0.05）。牙周炎患者的菌血症发生率略高，但无统计学意义。随着牙周炎阶段的进展，男性比例、年龄和住院时间显著增加。只有两名患者出现牙周并发症，均得到有效处理，未干扰移植过程。
牙周炎在血液病患者中普遍存在。尽管其与口腔黏膜炎有关，但牙周感染的发生率仍然较低且可控。
