Gounden Verena, Warasally Mohamed Zain, Magwai Thabo, Naidoo Rajen, Chuturgoon Anil
Department of Chemical Pathology, University of KwaZulu-Natal and National Health Laboratory Services, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Department of Chemical Pathology, National Health Laboratory Services, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Reprod Toxicol. 2021 Mar;100:83-89. doi: 10.1016/j.reprotox.2021.01.004. Epub 2021 Jan 13.
Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathology. The aim of this study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with sex steroid hormone levels in South African mother-child pairs. Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA, BPA-g and nine sex steroid hormones using liquid chromatography tandem mass spectrometry (LC-MS/MS). Sixty maternal and child pairs were analyzed. Rank correlation demonstrated a significant positive relationship between cord blood estradiol and cord blood BPA (p = 0.002) and maternal BPA levels (p = 0.02) respectively. Cord blood testosterone from male infants showed a negative Spearman's correlation (r=-0.5, p = 0.02) with maternal BPA-g. There was no statistical difference in total testosterone levels in cord blood from male and female infants. The findings of the current study indicate a significant relationship between some key sex steroid hormones namely testosterone, dihydrotestosterone and estradiol and fetal exposure BPA.
在早期发育过程中，尤其是在子宫内接触双酚A（BPA）与多种病理状况有关。本研究的目的是探讨南非母婴对中双酚A及其天然代谢产物双酚A葡萄糖醛酸苷（BPA-g）与性类固醇激素水平之间的关系。使用液相色谱串联质谱法（LC-MS/MS）分析了孕晚期母体血清样本和匹配的脐带血样本中的双酚A、双酚A葡萄糖醛酸苷和九种性类固醇激素。对60对母婴进行了分析。秩相关分析表明，脐带血雌二醇与脐带血双酚A（p = 0.002）和母体双酚A水平（p = 0.02）之间分别存在显著正相关。男婴脐带血睾酮与母体双酚A葡萄糖醛酸苷呈负Spearman相关性（r = -0.5，p = 0.02）。男婴和女婴脐带血中总睾酮水平无统计学差异。本研究结果表明，一些关键的性类固醇激素，即睾酮、二氢睾酮和雌二醇与胎儿接触双酚A之间存在显著关系。
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