仅表现为贫血的多发性骨髓瘤患者的特征和结局：一项回顾性多中心研究。
Characteristics and outcome of multiple myeloma patients presenting with anaemia only: A retrospective multi-centre study.
机构信息
Department of Hematology, Tel Aviv Sourasky Medical Center, Israel.
Department of Hematology, Hadassah-Hebrew University medical center, Jerusalem, Israel.
出版信息
Leuk Res. 2021 Feb;101:106498. doi: 10.1016/j.leukres.2020.106498. Epub 2020 Dec 31.
BACKGROUND
Multiple myeloma (MM) patients presenting with anaemia as their sole clinical manifestation are rare and not fully defined.
METHODS
Retrospective multi-site study comparing the characteristics and outcome of MM patients with anaemia only with matched patients, presenting with multi-organ disease.
RESULTS
Anaemia-only patients had a higher percentage of bone marrow monoclonal plasma cells group (median 60% [IQR 42-80%] vs. 37% [IQR 17-65%], respectively; p < 0.001), and a lower responsiveness to treatment (≥VGPR rates were 54% vs 74%, p = 0.049). Median survival in anaemia only patients was 65.9 ± 6.9 vs 83.4 ± 8.8 months in matched control patients (P = n.s).
CONCLUSIONS
MM patients presenting with anaemia only represents a unique, potentially less favorable population.
背景
仅有贫血表现的多发性骨髓瘤（MM）患者较为罕见，目前尚未对其进行充分定义。
方法
本回顾性多中心研究比较了仅有贫血的 MM 患者与具有多器官疾病的匹配患者的特征和预后。
结果
仅有贫血的患者骨髓单克隆浆细胞比例更高（中位数 60%[IQR 42-80%] vs. 37%[IQR 17-65%]；p<0.001），且治疗应答率较低（≥VGPR 率分别为 54% vs. 74%；p=0.049）。仅有贫血的患者中位生存期为 65.9±6.9 个月，而匹配对照患者为 83.4±8.8 个月（P=无统计学意义）。
结论
仅有贫血表现的 MM 患者可能是一个独特的、预后较差的人群。
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