Department of Psychiatry and Behavioral Neurosciences, USA; School of Medicine, Department of Internal Medicine Wayne State University, Detroit, MI 48201, USA.
School of Medicine, Department of Internal Medicine Wayne State University, Detroit, MI 48201, USA.
Drug Alcohol Depend. 2021 Mar 1;220:108524. doi: 10.1016/j.drugalcdep.2021.108524. Epub 2021 Jan 12.
Despite medicalization and legalization of marijuana use, factors influencing demand for marijuana among persons living with HIV (PLWH) are incompletely understood. This knowledge gap undermines effective clinical management and policies. This study used demand curve simulation methods to address these issues.
Marijuana-using PLWH (N = 119) completed experimental tasks to simulate amount of marijuana purchasing/use across different costs (money or time), and likelihood of reselling marijuana or marijuana therapeutic-use registration card in relation to profits. Additional simulations assessed purchasing of marijuana relative to other drug and non-drug goods.
Simulated marijuana use decreased as money and time costs increased. Consumption was greater for participants with more severe Cannabis Use Disorder (CUD) and anxiety, intermediate pain levels, and past 90-day opioid use. Whereas few participants chose to sell their registration card, marijuana resale (diversion) steeply increased with profit. Likelihood of seeking marijuana therapeutic-use certification decreased in relation to registration card money cost, having to visit more physicians to get a signature, and delay to receiving the card, and increased with duration of certification. Participants who reported recent opioid use were more likely to seek certification. Consumption of several commodities assessed was independent of marijuana.
Simulated marijuana use was related to participants' clinical profile (CUD, anxiety and pain symptoms, recent opioid use), and unrelated to purchasing other goods. Likelihood of seeking marijuana therapeutic-use registration was affected by several types of costs and recent opioid use. Participants were unlikely to divert registration cards. We discuss clinical and policy implications of these findings.
尽管大麻的使用已经被医学化和合法化，但在 HIV 感染者（PLWH）中，影响大麻需求的因素仍不完全清楚。这一知识空白削弱了有效的临床管理和政策。本研究使用需求曲线模拟方法来解决这些问题。
使用大麻的 PLWH（N=119）完成了实验任务，以模拟在不同成本（金钱或时间）下购买/使用大麻的数量，以及与利润相关的转售大麻或大麻治疗用途登记卡的可能性。其他模拟评估了与其他药物和非药物商品相比购买大麻的情况。
随着金钱和时间成本的增加，模拟的大麻使用量减少。大麻使用障碍（CUD）和焦虑症状更严重、中等疼痛水平和过去 90 天使用阿片类药物的参与者消费更多。虽然很少有参与者选择出售他们的登记卡，但随着利润的增加，大麻转售（滥用）急剧增加。寻求大麻治疗用途认证的可能性与登记卡的金钱成本、获得签名需要访问更多医生以及延迟获得卡片有关，而与认证的持续时间有关。最近使用阿片类药物的参与者更有可能寻求认证。评估的几种商品的消费与大麻无关。
模拟的大麻使用与参与者的临床特征（CUD、焦虑和疼痛症状、最近的阿片类药物使用）有关，与购买其他商品无关。寻求大麻治疗用途登记的可能性受到多种类型的成本和最近阿片类药物使用的影响。参与者不太可能滥用登记卡。我们讨论了这些发现的临床和政策意义。
