Center of Cancer, The First Affiliated Hospital of Jilin University, Changchun, China.
Center of Cancer, The First Affiliated Hospital of Jilin University, Changchun, China.
Nutrition. 2021 Apr;84:111110. doi: 10.1016/j.nut.2020.111110. Epub 2020 Dec 11.
The aims of this study was to investigate the association of phase angle (PA) with sarcopenia and its components and to evaluate the effectiveness of PA in sarcopenia diagnosis in older men (>65 y of age) with cancer.
The study included older men with non-small cell lung cancer and digestive tract cancer who were hospitalized in the past 3 y. General characteristics such as age, body mass index, and tumor stage were gathered. Mid-upper arm muscle circumstance, calf circumstance, and handgrip strength (HGS) were measured. PA and appendicular skeletal muscle mass were examined by bioelectrical impedance analysis. According to the diagnostic criteria of the 2019 consensus of Asian Sarcopenia Working Group, the patients were divided into two groups: non-sarcopenia and sarcopenia. The study included 445 patients with a 22.2% prevalence of sarcopenia.
PA was different between the non-sarcopenia and sarcopenia groups (5.02° versus 4.18°; P < 0.001). Pearson correlation showed that PA was related to diagnostic and confounding factors of sarcopenia. After adjusting for all potential confounding factors, multiple linear regression analysis showed diagnostic components of sarcopenia (HGS and skeletal muscle mass index [SMI]) could predict 25.3% of PA variation and logistic regression analysis showed PA (odds ratio, 0.309; P < 0.001) were related to sarcopenia. Then receiver operating characteristic curve showed the cutoff value of 4.25° with area under the curve of 0.785 for PA.
PA is related to diagnostic components of sarcopenia, HGS and SMI. PA can be useful in the diagnosis of sarcopenia in older male patients with cancer. The cutoff value proposed in this study was 4.25°.
本研究旨在探讨相位角（PA）与肌肉减少症及其组成部分的相关性，并评估 PA 在诊断年龄大于 65 岁（y）的癌症男性患者肌肉减少症中的有效性。
该研究纳入了过去 3 年内因非小细胞肺癌和消化道癌症住院的老年男性患者。收集了年龄、体重指数和肿瘤分期等一般特征。测量了中上臂肌肉围度、小腿围度和握力（HGS）。通过生物电阻抗分析检查 PA 和四肢骨骼肌质量。根据 2019 年亚洲肌肉减少症工作组共识的诊断标准，将患者分为非肌肉减少症和肌肉减少症两组。该研究共纳入 445 例患者，肌肉减少症患病率为 22.2%。
非肌肉减少症和肌肉减少症组之间的 PA 存在差异（5.02°与 4.18°；P<0.001）。Pearson 相关分析显示，PA 与肌肉减少症的诊断和混杂因素相关。在校正所有潜在混杂因素后，多元线性回归分析显示，肌肉减少症的诊断成分（HGS 和骨骼肌质量指数[SMI]）可以预测 PA 变化的 25.3%，逻辑回归分析显示 PA（比值比，0.309；P<0.001）与肌肉减少症相关。然后，受试者工作特征曲线显示 PA 的截断值为 4.25°，曲线下面积为 0.785。
PA 与肌肉减少症的诊断成分 HGS 和 SMI 相关。PA 可用于诊断老年男性癌症患者的肌肉减少症。本研究提出的截断值为 4.25°。
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