Medical Imaging Center, First affiliated hospital of JINAN University, Guangzhou, 510630, China.
Medical Imaging Center, First affiliated hospital of JINAN University, Guangzhou, 510630, China.
Psychiatry Res Neuroimaging. 2021 Feb 28;308:111239. doi: 10.1016/j.pscychresns.2020.111239. Epub 2020 Dec 31.
Anhedonia is a core symptom of major depressive disorder (MDD). Two subtypes of anhedonia: anticipatory anhedonia and consummatory anhedonia has been recognized in MDD patients. However, our knowledge regarding the distinction of anticipatory anhedonia and consummatory anhedonia in MDD remains limited. This study aimed to characterize the anticipatory anhedonia and consummatory anhedonia in first-episode, drug-naïve MDD patients. Resting-state functional MRI and T1-structural MRI were acquired for 38 MDD patients and 65 matched healthy controls (HCs). The ALFF and cortical surface indexes were compared between MDD and HCs. Then the correlations between the ALFF and cortical surface indexes alternations and the scores of anticipatory and consummatory pleasure measured by Temporal Experience of Pleasure Scale were evaluated. The elevated ALFF of left dorsal anterior cingulate cortex (dACC) and the reduced cortical thickness (CT) of left rostral ACC and lateral orbitofrontal cortex (lOFC) were respectively correlated with anticipatory anhedonia and consummatory anhedonia in MDD patients. These findings suggested the dissociated pathophysiological basis and imaging characteristics of anticipatory anhedonia and consummatory anhedonia. The ALFF and CT values of ACC and lOFC might serve as the imaging biomarker of the subtypes of anhedonia in early onset of MDD.
快感缺失是重性抑郁障碍（MDD）的核心症状。在 MDD 患者中已经认识到两种快感缺失亚型：预期性快感缺失和满足性快感缺失。然而，我们对于 MDD 中预期性快感缺失和满足性快感缺失的区别的了解仍然有限。本研究旨在描述首发、未用药的 MDD 患者的预期性快感缺失和满足性快感缺失。对 38 名 MDD 患者和 65 名匹配的健康对照者（HCs）进行静息态功能磁共振成像（rs-fMRI）和 T1 结构磁共振成像（T1-MRI）采集。比较 MDD 组和 HCs 组的局部一致性（ALFF）和皮质表面指标。然后评估 ALFF 和皮质表面指标变化与时间体验快感量表（Temporal Experience of Pleasure Scale）测量的预期和满足性快感评分之间的相关性。左侧背侧前扣带皮层（dACC）的 ALFF 升高和左侧额极前回和外侧眶额皮层（lOFC）的皮质厚度（CT）降低与 MDD 患者的预期性快感缺失和满足性快感缺失分别相关。这些发现表明预期性快感缺失和满足性快感缺失具有不同的病理生理基础和影像学特征。ACC 和 lOFC 的 ALFF 和 CT 值可能是 MDD 早期发病的快感缺失亚型的影像学生物标志物。
