Ethridge C P, Mitchell G M, Barton R M, Morrison W A, O'Brien B M
Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Victoria, Australia.
Br J Plast Surg. 1988 Jan;41(1):52-61. doi: 10.1016/0007-1226(88)90145-2.
In this study the patency of long microvenous allografts in rabbits with and without immunosuppressive drug therapy was investigated. Eighty-two microvenous autografts (controls) and allografts were transplanted into rabbit femoral vessels. Veno-venous autograft controls were 100% patent at 3 weeks. Rejection of non-immunosuppressed veno-venous allografts consistently produced occlusion between 15-20 days. Thrombus filled the lumen, and a leucocyte invasion destroyed the graft wall. In contrast vein allografts into arteries were 100% patent at 3 weeks; this was reduced to 50% at 4 weeks. Low (5 mg/kg/day) and high (20 mg/kg/day) doses of hydrocortisone over 21 days improved the 3 week patency in veno-venous allografts to 28.5% and 57.0% respectively. Cyclosporin A (15 mg/kg/day) over 8 or 22 days significantly increased the patency rate of veno-venous allografts to 100%. Only cyclosporin A treated rabbits maintained allografts of normal vein morphology to 3 weeks.
在本研究中，对接受和未接受免疫抑制药物治疗的家兔体内长段异体微静脉移植血管的通畅情况进行了研究。将82个自体微静脉移植血管（对照组）和异体微静脉移植血管移植到家兔股血管中。静脉-静脉自体移植对照组在3周时通畅率为100%。未接受免疫抑制的静脉-静脉异体移植血管在15至20天之间持续发生排斥反应并导致血管闭塞。血栓充满管腔，白细胞浸润破坏了移植血管壁。相比之下，静脉异体移植血管植入动脉的情况在3周时通畅率为100%；4周时降至50%。连续21天给予低剂量（5毫克/千克/天）和高剂量（20毫克/千克/天）的氢化可的松，可使静脉-静脉异体移植血管在3周时的通畅率分别提高到28.5%和57.0%。给予环孢素A（15毫克/千克/天）8天或22天，可使静脉-静脉异体移植血管的通畅率显著提高到100%。只有接受环孢素A治疗的家兔的异体移植血管在3周时仍保持正常静脉形态。
