Mitchell G M, Zeeman B J, Rogers I W, Pribaz J J, O'Brien B M
Microsurgery Research Centre, St. Vincent's Hospital, Melbourne, Australia.
Plast Reconstr Surg. 1988 Sep;82(3):473-9. doi: 10.1097/00006534-198809000-00018.
Changes in length, external diameter, wall thickness, and morphology were examined in 60 intraarterial vein grafts and 30 intravenous vein grafts inserted in rabbit femoral vessels. Half of each graft type was explored at 6 or 12 months, giving four experimental groups. The overall patency for intraarterial grafts at exploration was 98 percent and for intravenous grafts 100 percent. In comparison with the initial graft length resected, all four groups were significantly shorter at the completion of anastomosis, and three of the four groups also were significantly shorter at exploration. The overall loss in length of grafts varied between 26 and 30 percent of original length. External diameter was significantly increased (from between 133 and 201 percent) in all four groups at exploration compared to the normal femoral vein. Intravenous grafts maintained normal vein morphology to 12 months. Intraarterial grafts were modified by the ingrowth of smooth-muscle cells from the recipient artery, thereby creating a neointima that significantly thickened their walls at both 6 and 12 months.
对植入兔股血管的60个动脉化静脉移植物和30个静脉移植物的长度、外径、壁厚及形态变化进行了检查。每种移植物类型的一半在6个月或12个月时进行探查，分为四个实验组。探查时动脉化移植物的总体通畅率为98%，静脉移植物为100%。与最初切除的移植物长度相比，所有四组在吻合完成时均显著缩短，且四组中有三组在探查时也显著缩短。移植物长度的总体损失在原始长度的26%至30%之间。与正常股静脉相比，所有四组在探查时外径均显著增加（从133%至201%）。静脉移植物在12个月内保持正常静脉形态。动脉化移植物因受者动脉平滑肌细胞向内生长而发生改变，从而形成新生内膜，在6个月和12个月时均使其壁显著增厚。
