胼胝体：性别、早期经历和年龄的区域特异性影响。

Corpus callosum: region-specific effects of sex, early experience and age.

作者信息

Berrebi A S, Fitch R H, Ralphe D L, Denenberg J O, Friedrich V L, Denenberg V H

机构信息

Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs 06268.

出版信息

Brain Res. 1988 Jan 12;438(1-2):216-24. doi: 10.1016/0006-8993(88)91340-6.

DOI:10.1016/0006-8993(88)91340-6

PMID:3345428

Abstract

In infancy, rats were provided handling stimulation and compared at 110 and 215 days of age with non-handled controls. Measurements were made of corpus callosum area, perimeter and length; and width measures were taken at 7 points along the longitudinal axis of the callosum. Callosal size was larger in males than in females, even when adjusted for the larger brain weight of the male. At 110 days handling stimulation increased callosal parameters and resulted in a more regular callosum in males, but this effect was no longer apparent by 215 days. Within the callosum, region-specific effects were found, suggesting that certain callosal fiber populations were involved. Handled males have previously been shown to be more lateralized than non-handled males; thus at least in this experimental system, increased callosal size and regularity is associated with greater hemispheric specialization.

摘要

在幼年期，给予大鼠触觉刺激，并在110日龄和215日龄时与未接受触觉刺激的对照组进行比较。测量胼胝体的面积、周长和长度；并在胼胝体纵轴上的7个点进行宽度测量。即使考虑到雄性大鼠脑重量较大的因素，雄性大鼠的胼胝体大小仍大于雌性大鼠。在110日龄时，触觉刺激增加了胼胝体参数，并使雄性大鼠的胼胝体更加规则，但到215日龄时这种效果不再明显。在胼胝体内，发现了区域特异性效应，这表明某些胼胝体纤维群体参与其中。先前已表明，接受触觉刺激的雄性大鼠比未接受刺激的雄性大鼠更具偏侧化；因此，至少在这个实验系统中，胼胝体大小和规则性的增加与更大程度的半球特化相关。