Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany.
Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany.
Exp Eye Res. 2021 Mar;204:108432. doi: 10.1016/j.exer.2020.108432. Epub 2021 Jan 14.
Ionising radiation interacts with lenses and retinae differently. In human lenses, posterior subcapsular cataracts are the predominant observation, whereas retinae of adults are comparably resistant to even relatively high doses. In this study, we demonstrate the effects of 2 Gy of low linear energy transfer ionising radiation on eyes of B6C3F1 mice aged postnatal day 2. Optical coherence tomography and Scheimpflug imaging were utilised for the first time to monitor murine lenses and retinae in vivo. The visual acuity of the mice was determined and histological analysis was conducted. Our results demonstrated that visual acuity was reduced by as much as 50 % approximately 9 months after irradiation in irradiated mice. Vision impairment was caused by retinal atrophy and inner cortical cataracts. These results help to further our understanding of the risk of ionising radiation for human foeti (∼ 8 mo), which follow the same eye development stages as neonatal mice.
电离辐射与晶状体和视网膜的相互作用方式不同。在人眼晶状体中，后囊下白内障是主要观察到的现象，而成年人的视网膜即使受到相对较高的剂量也具有相当的抗性。在这项研究中，我们展示了 2Gy 低线性能量转移电离辐射对出生后第 2 天的 B6C3F1 小鼠眼睛的影响。首次利用光学相干断层扫描和 Scheimpflug 成像技术在体监测小鼠晶状体和视网膜。测定了小鼠的视力，并进行了组织学分析。我们的结果表明，大约在照射后 9 个月，受照射的小鼠的视力下降了多达 50%。视力损伤是由视网膜萎缩和内皮质白内障引起的。这些结果有助于进一步了解对处于类似眼发育阶段的人类胎儿（约 8 个月）的电离辐射风险。
