Universidad Pablo de Olavide, Centro Andaluz de Biología Del Desarrollo, CABD-CSIC, CIBERER, Instituto de Salud Carlos III, Carretera de Utrera Km. 1, 41013, Sevilla, Spain.
Free Radic Biol Med. 2021 Feb 20;164:285-302. doi: 10.1016/j.freeradbiomed.2021.01.024. Epub 2021 Jan 14.
Coenzyme Q (CoQ) is a key component for many essential metabolic and antioxidant activities in cells in mitochondria and cell membranes. Mitochondrial dysfunction is one of the hallmarks of aging and age-related diseases. Deprivation of CoQ during aging can be the cause or the consequence of this mitochondrial dysfunction. In any case, it seems clear that aging-associated CoQ deprivation accelerates mitochondrial dysfunction in these diseases. Non-genetic prolongevity interventions, including CoQ dietary supplementation, can increase CoQ levels in mitochondria and cell membranes improving mitochondrial activity and delaying cell and tissue deterioration by oxidative damage. In this review, we discuss the importance of CoQ deprivation in aging and age-related diseases and the effect of prolongevity interventions on CoQ levels and synthesis and CoQ-dependent antioxidant activities.
辅酶 Q（CoQ）是线粒体和细胞膜中许多重要代谢和抗氧化活性的关键组成部分。线粒体功能障碍是衰老和与年龄相关疾病的特征之一。衰老过程中 CoQ 的剥夺可能是这种线粒体功能障碍的原因或结果。在任何情况下，与衰老相关的 CoQ 剥夺似乎都会加速这些疾病中线粒体功能障碍的发生。非遗传的长寿干预措施，包括 CoQ 的饮食补充，可以增加线粒体和细胞膜中的 CoQ 水平，改善线粒体活性，通过氧化损伤延缓细胞和组织的恶化。在这篇综述中，我们讨论了 CoQ 剥夺在衰老和与年龄相关疾病中的重要性，以及长寿干预措施对 CoQ 水平和合成以及 CoQ 依赖性抗氧化活性的影响。
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