从中国野生鸟类中分离到的新型重配 H6 病毒的遗传特征和致病性。
Genetic characteristics and pathogenicity of novel reassortant H6 viruses isolated from wild birds in China.
机构信息
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
出版信息
Vet Microbiol. 2021 Mar;254:108978. doi: 10.1016/j.vetmic.2021.108978. Epub 2021 Jan 6.
During our routine surveillance, we isolated seven H6 avian influenza virus (AIV) strains, including three H6N1 strains, three H6N2 strains, and one H6N8 strain, from 3667 fresh fecal samples that were collected from wild bird habitats in China from March 2017 and May 2019. Phylogenetic analysis revealed that these viruses formed five different genotypes and have undergone complicate reassortment during their evolution by acquiring genes from AIVs of both Eurasian and North American lineages that have been previously detected in migrating waterfowl and poultry. Viral pathogenesis in mice showed that these H6 viruses replicated efficiently in both the nasal turbinates and lungs of mice without pre-adaptation, but none of them were lethal for mice. We studied the genetic characteristic and biological property of novel reassortant H6 viruses isolated from wild birds in China. It also highlights the need for continued surveillance of H6 AIVs circulating in nature.
在常规监测中，我们从 2017 年 3 月至 2019 年 5 月在中国野生鸟类栖息地收集的 3667 份新鲜粪便样本中分离出了 7 株 H6 禽流感病毒（AIV）株，包括 3 株 H6N1 株、3 株 H6N2 株和 1 株 H6N8 株。系统进化分析显示，这些病毒形成了 5 种不同的基因型，并在进化过程中通过从以前在迁徙水禽和家禽中检测到的欧亚和北美谱系的 AIV 中获得基因，经历了复杂的重配。在小鼠中的病毒发病机制研究表明，这些 H6 病毒在未经预先适应的情况下在小鼠的鼻甲骨和肺部中高效复制，但对小鼠均无致死性。我们研究了从中国野生鸟类中分离出的新型重配 H6 病毒的遗传特征和生物学特性。这也凸显了需要持续监测在自然界中传播的 H6 AIV。
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